Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase
U Landmesser, S Spiekermann, S Dikalov, H Tatge… - Circulation, 2002 - Am Heart Assoc
Background—Impaired flow-dependent, endothelium-mediated vasodilation (FDD) in
patients with chronic heart failure (CHF) results, at least in part, from accelerated …
patients with chronic heart failure (CHF) results, at least in part, from accelerated …
[HTML][HTML] Redox signaling in cardiac myocytes
CXC Santos, N Anilkumar, M Zhang, AC Brewer… - Free Radical Biology …, 2011 - Elsevier
The heart has complex mechanisms that facilitate the maintenance of an oxygen supply–
demand balance necessary for its contractile function in response to physiological …
demand balance necessary for its contractile function in response to physiological …
Impact of oxypurinol in patients with symptomatic heart failure: results of the OPT-CHF study
Objectives: This study evaluated whether a xanthine oxidase (XO) inhibitor, oxypurinol,
produces clinical benefits in patients with New York Heart Association functional class III to …
produces clinical benefits in patients with New York Heart Association functional class III to …
The role of oxidative stress in the aging heart
Medical advances and the availability of diagnostic tools have considerably increased life
expectancy and, consequently, the elderly segment of the world population. As age is a …
expectancy and, consequently, the elderly segment of the world population. As age is a …
Metabolic remodelling of the failing heart: the cardiac burn-out syndrome?
M van Bilsen, PJH Smeets, AJ Gilde… - Cardiovascular …, 2004 - academic.oup.com
It has been postulated that the failing heart suffers from chronic energy starvation, and that
derangements in cardiac energy conversion are accessory to the progressive nature of this …
derangements in cardiac energy conversion are accessory to the progressive nature of this …
[HTML][HTML] Oxidant stress from nitric oxide synthase–3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load
E Takimoto, HC Champion, M Li, S Ren… - The Journal of …, 2005 - Am Soc Clin Investig
Cardiac pressure load stimulates hypertrophy, often leading to chamber dilation and
dysfunction. ROS contribute to this process. Here we show that uncoupling of nitric oxide …
dysfunction. ROS contribute to this process. Here we show that uncoupling of nitric oxide …
Positive inotropic and lusitropic effects of HNO/NO− in failing hearts: Independence from β-adrenergic signaling
N Paolocci, T Katori, HC Champion… - Proceedings of the …, 2003 - National Acad Sciences
Nitroxyl anion (HNO/NO−), the one-electron reduced form of nitric oxide (NO), induces
positive cardiac inotropy and selective venodilation in the normal in vivo circulation. Here we …
positive cardiac inotropy and selective venodilation in the normal in vivo circulation. Here we …
Protein nitration in cardiovascular diseases
IV Turko, F Murad - Pharmacological reviews, 2002 - ASPET
There is growing evidence that cardiovascular disease is associated with progressive
changes in the production of free radicals and radical-derived reactive species. These …
changes in the production of free radicals and radical-derived reactive species. These …
NO/redox disequilibrium in the failing heart and cardiovascular system
JM Hare, JS Stamler - The Journal of clinical investigation, 2005 - Am Soc Clin Investig
There is growing evidence that the altered production and/or spatiotemporal distribution of
reactive oxygen and nitrogen species creates oxidative and/or nitrosative stresses in the …
reactive oxygen and nitrogen species creates oxidative and/or nitrosative stresses in the …
Nitric oxide and cardiac function
R Rastaldo, P Pagliaro, S Cappello, C Penna… - Life sciences, 2007 - Elsevier
Nitric oxide (NO) participates in the control of contractility and heart rate, limits cardiac
remodeling after an infarction and contributes to the protective effect of ischemic pre-and …
remodeling after an infarction and contributes to the protective effect of ischemic pre-and …