Background—Impaired flow-dependent, endothelium-mediated vasodilation (FDD) in
patients with chronic heart failure (CHF) results, at least in part, from accelerated …

The heart has complex mechanisms that facilitate the maintenance of an oxygen supply–
demand balance necessary for its contractile function in response to physiological …

Objectives: This study evaluated whether a xanthine oxidase (XO) inhibitor, oxypurinol,
produces clinical benefits in patients with New York Heart Association functional class III to …

Medical advances and the availability of diagnostic tools have considerably increased life
expectancy and, consequently, the elderly segment of the world population. As age is a …

It has been postulated that the failing heart suffers from chronic energy starvation, and that
derangements in cardiac energy conversion are accessory to the progressive nature of this …

Cardiac pressure load stimulates hypertrophy, often leading to chamber dilation and
dysfunction. ROS contribute to this process. Here we show that uncoupling of nitric oxide …

Nitroxyl anion (HNO/NO−), the one-electron reduced form of nitric oxide (NO), induces
positive cardiac inotropy and selective venodilation in the normal in vivo circulation. Here we …

There is growing evidence that cardiovascular disease is associated with progressive
changes in the production of free radicals and radical-derived reactive species. These …

There is growing evidence that the altered production and/or spatiotemporal distribution of
reactive oxygen and nitrogen species creates oxidative and/or nitrosative stresses in the …

Nitric oxide (NO) participates in the control of contractility and heart rate, limits cardiac
remodeling after an infarction and contributes to the protective effect of ischemic pre-and …