Oxidative stress plays an important role in the progression of vascular endothelial
dysfunction. The two major systems generating vascular oxidative stress are the NADPH …

Over the last two decades, it has become increasingly clear that reactive oxygen species
(ROS), including free radicals are involved in cardiovascular disease. In recent years, there …

Significance: The regulation of myocardial function by constitutive nitric oxide synthases
(NOS) is important for the maintenance of myocardial Ca2+ homeostasis, relaxation and …

Background Hyperuricemia is associated with reduced survival among patients with heart
failure (HF), but the effect of gout on HF outcomes is unknown. A recent randomized trial …

In the current issue of Circulation, Anker and colleagues1 report that elevated levels of uric
acid (UA) predict mortality and the need for heart transplantation in patients with congestive …

Spinal muscular atrophy (SMA) is an autosomal recessive disorder, which is the leading
genetic cause of infantile death. SMA is the most common inherited motor neuron disease …

Although interactions between superoxide () and nitric oxide underlie many physiologic and
pathophysiologic processes, regulation of this crosstalk at the enzymatic level is poorly …

Background—Phosphodiesterase type 5 (PDE5) inhibition has been shown to exert
profound beneficial effects in the failing heart, suggesting a significant role for PDE5 in the …

Heart failure is the major cause of hospitalization, morbidity and mortality worldwide.
Previous experimental and clinical studies have suggested that there is an increased …

This study was designed to investigate the protective effect of curcumin (CUR) against
isoprenaline induced myocardial ischaemia in rat myocardium. The effect of single oral dose …