Many studies have shown a strong correlation between urate levels and cardiovascular
disease. The formation of urate is complex as the same enzyme that produces urate …

Nitric oxide is a key player among the numerous mediators of endothelial homeostasis and
cardiac contractility and is thereby involved in the pathogenic processes leading to vascular …

Chronic heart failure (CHF), the new epidemic in cardiology, is characterized by energetic
failure of both cardiac and skeletal muscles. The failing heart wastes energy due to …

Reactive oxygen species, in particular superoxide, have been closely linked to the
underlying pathophysiology of ischemic cardiomyopathy: superoxide not only mediates …

QSOX1, a sulfhydryl oxidase, was shown to be upregulated in the heart upon acute heart
failure (AHF). The aim of the study was to unravel QSOX1 roles during AHF. We generated …

BACKGROUND: Oxidative stress is linked with several cardiovascular diseases. However,
the NADPH oxidase activity in severe mitral regurgitation patients with and without atrial …

Uric acid (UA) is the end product of purine metabolism in humans. Hyperuricemia is often
found in patients with chronic heart failure (CHF). The increase of serum UA level is …

BACKGROUND: Nitric oxide (NO), a highly versatile signaling molecule, exerts a broad
range of regulatory influences in the cardiovascular system that extends from vasodilation to …

Objective To investigate the therapeutic effect of allopurinol treatment on acute coronary
syndrome and to elucidate its possible mechanism. Methods Patients with acute coronary …

Experimental studies have suggested that TNFα, a pro-inflammatory cytokine, may
contribute to the deterioration of cardiovascular function through various mechanisms …