[HTML][HTML] Targeted therapy of kidney disease with nanoparticle drug delivery materials

S Shang, X Li, H Wang, Y Zhou, K Pang, P Li, X Liu… - Bioactive Materials, 2024 - Elsevier
With the development of nanomedicine, nanomaterials have been widely used, offering
specific drug delivery to target sites, minimal side effects, and significant therapeutic effects …

[HTML][HTML] From AKI to CKD: maladaptive repair and the underlying mechanisms

Z Wang, C Zhang - International journal of molecular sciences, 2022 - mdpi.com
Acute kidney injury (AKI) is defined as a pathological condition in which the glomerular
filtration rate decreases rapidly over a short period of time, resulting in changes in the …

1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic Acid Acetoxymethyl Ester Loaded Reactive Oxygen Species Responsive Hyaluronic Acid–Bilirubin …

Y Wang, M Pu, J Yan, J Zhang, H Wei, L Yu, X Yan… - ACS …, 2022 - ACS Publications
Calcium overload is one of the early determinants of the core cellular events that contribute
to the pathogenesis of acute kidney injury (AKI), which include oxidative stress, ATP …

Supramolecular integration of multifunctional nanomaterial by mannose-decorated azocalixarene with ginsenoside Rb1 for synergistic therapy of rheumatoid arthritis

S Li, JJ Li, YY Zhao, MM Chen, SS Su, SY Yao… - ACS …, 2023 - ACS Publications
The complexity and progressive nature of diseases require the exploitation of multifunctional
materials. However, introducing a function inevitably increases the complexity of materials …

[HTML][HTML] METTL3-mediated N6-methyladenosine modification stimulates mitochondrial damage and ferroptosis of kidney tubular epithelial cells following acute kidney …

C Hu, B Zhang, S Zhao - European Journal of Medicinal Chemistry, 2023 - Elsevier
Abstract N6-methyladenosine (m 6 A) and MELLT3 assume a role in the development of
acute kidney injury (AKI). However, their mechanism in AKI remains under-explored. On this …

Delivery of nitric oxide with a pH-responsive nanocarrier for the treatment of renal fibrosis

TY Lee, HH Lu, HT Cheng, HC Huang, YJ Tsai… - Journal of Controlled …, 2023 - Elsevier
Fibrosis is an excessive accumulation of extracellular matrix (ECM) that may cause severe
organ dysfunction. Nitric oxide (NO), a multifunctional gaseous signaling molecule, may …

Dual-responsive curcumin-loaded nanoparticles for the treatment of cisplatin-induced acute kidney injury

T Lan, H Guo, X Lu, K Geng, L Wu, Y Luo… - …, 2022 - ACS Publications
Acute kidney injury (AKI) has been a global public health concern leading to high patient
morbidity and mortality in the world. Nanotechnology-mediated antioxidative therapy has …

[HTML][HTML] Nanodrugs alleviate acute kidney injury: Manipulate RONS at kidney

Q Chen, Y Nan, Y Yang, Z Xiao, M Liu, J Huang… - Bioactive materials, 2023 - Elsevier
Currently, there are no clinical drugs available to treat acute kidney injury (AKI). Given the
high prevalence and high mortality rate of AKI, the development of drugs to effectively treat …

Reactive oxygen/nitrogen species scavenging and inflammatory regulation by renal-targeted bio-inspired rhodium nanozymes for acute kidney injury theranostics

Y Zheng, H Yi, Z Zhan, SS Xue, G Tang, X Yu… - Journal of Colloid and …, 2024 - Elsevier
Acute kidney injury (AKI) results from the rapid deterioration of renal function, which is
mainly treated by transplantation and dialysis, and has a high mortality rate. Inflammation …

[HTML][HTML] Tailored functionalized protein nanocarriers for cancer therapy: recent developments and prospects

MAA Abdelhamid, MR Ki, AAA El-Hafeez, RG Son… - Pharmaceutics, 2023 - mdpi.com
Recently, the potential use of nanoparticles for the targeted delivery of therapeutic and
diagnostic agents has garnered increased interest. Several nanoparticle drug delivery …