The global NAFLD epidemic

R Loomba, AJ Sanyal - Nature reviews Gastroenterology & hepatology, 2013 - nature.com
NAFLD is a clinical syndrome characterized by predominant macrovesicular steatosis of the
liver. The clinical and histological phenotypes of NAFLD extend from a nonalcoholic fatty …

[HTML][HTML] Nonalcoholic fatty liver disease: Evolving paradigms

A Lonardo, F Nascimbeni, M Maurantonio… - World journal of …, 2017 - ncbi.nlm.nih.gov
In the last years new evidence has accumulated on nonalcoholic fatty liver disease (NAFLD)
challenging the paradigms that had been holding the scene over the previous 30 years …

Glucocorticoids and non-alcoholic fatty liver disease

CP Woods, JM Hazlehurst, JW Tomlinson - The Journal of steroid …, 2015 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the global obesity
and metabolic disease epidemic and is rapidly becoming the leading cause of liver cirrhosis …

[HTML][HTML] Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity

J Massart, K Begriche, C Moreau… - Journal of clinical and …, 2017 - ncbi.nlm.nih.gov
Background: Obesity is often associated with nonalcoholic fatty liver disease (NAFLD),
which refers to a large spectrum of hepatic lesions including fatty liver, nonalcoholic …

The independent predictors of non‐alcoholic steatohepatitis and its individual histological features. Insulin resistance, serum uric acid, metabolic syndrome, alanine …

S Ballestri, F Nascimbeni, D Romagnoli… - Hepatology …, 2016 - Wiley Online Library
Aim The diagnosis of non‐alcoholic steatohepatitis (NASH) is based on the individual
histological features: steatosis, lobular inflammation and ballooning. Non‐alcoholic fatty liver …

Drug-induced liver injury in obesity and nonalcoholic fatty liver disease

J Allard, D Le Guillou, K Begriche… - Advances in Pharmacology, 2019 - Elsevier
Obesity is commonly associated with nonalcoholic fatty liver (NAFL), a benign condition
characterized by hepatic lipid accumulation. However, NAFL can progress in some patients …

Role of cannabis in digestive disorders

H Goyal, U Singla, U Gupta, E May - European journal of …, 2017 - journals.lww.com
Cannabis sativa, a subspecies of the Cannabis plant, contains aromatic hydrocarbon
compounds called cannabinoids.∆ 9-Tetrahydrocannabinol is the most abundant …

[HTML][HTML] Drug-induced fatty liver disease: An overview of pathogenesis and management

SK Satapathy, V Kuwajima, J Nadelson, O Atiq… - Annals of hepatology, 2015 - Elsevier
Over the past decades, many drugs have been identified, that can potentially induce
steatohepatitis in the predisposed individual. Classically this has been incriminated to …

[PDF][PDF] The selective peroxisome proliferator–activated receptor‐delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in …

F Haczeyni, H Wang, V Barn, AR Mridha… - Hepatology …, 2017 - Wiley Online Library
Lipotoxicity associated with insulin resistance is central to nonalcoholic steatohepatitis
(NASH) pathogenesis. To date, only weight loss fully reverses NASH pathology, but mixed …

[HTML][HTML] Controversies in the diagnosis and management of NAFLD and NASH

ME Rinella, R Loomba, SH Caldwell… - Gastroenterology & …, 2014 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is recognized as the most common cause of
chronic liver disease in the United States. Nonalcoholic steatohepatitis (NASH) occurs in a …