The incompletely fulfilled promise of embryo transfer in cattle—why aren't pregnancy rates greater and what can we do about it?

PJ Hansen - Journal of Animal Science, 2020 - academic.oup.com
Typically, bovine embryos are transferred into recipient females about day 7 after estrus or
anticipated ovulation, when the embryo has reached the blastocyst stage of development …

Strategies for modelling endometrial diseases

AR Murphy, H Campo, JJ Kim - Nature Reviews Endocrinology, 2022 - nature.com
Each month during a woman's reproductive years, the endometrium undergoes vast
changes to prepare for a potential pregnancy. Diseases of the endometrium arise for …

[HTML][HTML] Future regenerative medicine developments and their therapeutic applications

AE Altyar, A El-Sayed, A Abdeen, M Piscopo… - Biomedicine & …, 2023 - Elsevier
Although the currently available pharmacological assays can cure most pathological
disorders, they have limited therapeutic value in relieving certain disorders like myocardial …

Generation of offspring-producing 3D ovarian organoids derived from female germline stem cells and their application in toxicological detection

X Li, M Zheng, B Xu, D Li, Y Shen, Y Nie, L Ma, J Wu - Biomaterials, 2021 - Elsevier
In vitro production of oocytes capable of producing offspring has exciting potential
applications in reproductive medicine. Here, we generated and characterized an ovarian …

Novel microarchitecture of human endometrial glands: implications in endometrial regeneration and pathologies

N Tempest, CJ Hill, A Maclean… - Human …, 2022 - academic.oup.com
BACKGROUND Human endometrium remains a poorly understood tissue of the female
reproductive tract. The superficial endometrial functionalis, the site of embryo implantation, is …

Capture and metabolomic analysis of the human endometrial epithelial organoid secretome

CA Simintiras, P Dhakal, C Ranjit… - Proceedings of the …, 2021 - National Acad Sciences
Suboptimal uterine fluid (UF) composition can lead to pregnancy loss and likely contributes
to offspring susceptibility to chronic adult-onset disorders. However, our understanding of …

Human organoid systems in modeling reproductive tissue development, function, and disease

S Haider, AG Beristain - Human Reproduction, 2023 - academic.oup.com
Research focused on human reproductive biology has primarily relied upon clinical samples
affording mainly descriptive studies with limited implementation of functional or mechanistic …

[HTML][HTML] Biomaterial strategies for the application of reproductive tissue engineering

X Liu, K Wu, L Gao, L Wang, X Shi - Bioactive Materials, 2022 - Elsevier
Human reproductive organs are of vital importance to the life of an individual and the
reproduction of human populations. So far, traditional methods have a limited effect in …

[HTML][HTML] Collagen I triggers directional migration, invasion and matrix remodeling of stroma cells in a 3D spheroid model of endometriosis

A Stejskalová, V Fincke, M Nowak, Y Schmidt… - Scientific reports, 2021 - nature.com
Endometriosis is a painful gynecological condition characterized by ectopic growth of
endometrial cells. Little is known about its pathogenesis, which is partially due to a lack of …

[HTML][HTML] The role of BMP signaling in female reproductive system development and function

E Magro-Lopez, MÁ Muñoz-Fernández - International journal of molecular …, 2021 - mdpi.com
Bone morphogenetic proteins (BMPs) are a group of multifunctional growth factors that
belong to the transforming growth factor-β (TGF-β) superfamily of proteins. Originally …