[HTML][HTML] Advances in the study of exosomes derived from mesenchymal stem cells and cardiac cells for the treatment of myocardial infarction

Y Liu, M Wang, Y Yu, C Li, C Zhang - Cell Communication and Signaling, 2023 - Springer
Acute myocardial infarction has long been the leading cause of death in coronary heart
disease, which is characterized by irreversible cardiomyocyte death and restricted blood …

[HTML][HTML] Treatment of Alzheimer's disease: beyond symptomatic therapies

FR Buccellato, M D'Anca, GM Tartaglia… - International Journal of …, 2023 - mdpi.com
In an ever-increasing aged world, Alzheimer's disease (AD) represents the first cause of
dementia and one of the first chronic diseases in elderly people. With 55 million people …

[HTML][HTML] Reprogramming macrophages via immune cell mobilized hydrogel microspheres for osteoarthritis treatments

P Xiao, X Han, Y Huang, J Yang, L Chen, Z Cai, N Hu… - Bioactive Materials, 2024 - Elsevier
Regulating macrophage activation precisely is crucial in treating chronic inflammation in
osteoarthritis (OA). However, the stable pro-inflammatory state and deep distribution of …

Emerging nanotechnology for Alzheimer's disease: From detection to treatment

N Song, S Sun, K Chen, Y Wang, H Wang… - Journal of Controlled …, 2023 - Elsevier
Abstract Alzheimer's disease (AD), one of the most common chronic neurodegenerative
diseases, is characterized by memory impairment, synaptic dysfunction, and character …

[HTML][HTML] Amyloid Precursor Protein and Alzheimer's Disease

KS Orobets, AL Karamyshev - International Journal of Molecular Sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders
associated with age or inherited mutations. It is characterized by severe dementia in the late …

[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles: An emerging diagnostic and therapeutic biomolecules for neurodegenerative disabilities

M Kandeel, MA Morsy, KM Alkhodair, S Alhojaily - Biomolecules, 2023 - mdpi.com
Mesenchymal stem cells (MSCs) are a type of versatile adult stem cells present in various
organs. These cells give rise to extracellular vesicles (EVs) containing a diverse array of …

Therapeutic efficacy and promise of stem cell-derived extracellular vesicles in Alzheimer's disease and other aging-related disorders

HA Rather, S Almousa, S Craft, G Deep - Ageing Research Reviews, 2023 - Elsevier
The term extracellular vesicles (EVs) refers to a variety of heterogeneous nanovesicles
secreted by almost all cell types, primarily for intercellular communication and maintaining …

[HTML][HTML] An update on stem cell and stem cell-derived extracellular vesicle-based therapy in the management of Alzheimer's disease

M Jeyaraman, RL Rajendran, S Muthu, N Jeyaraman… - Heliyon, 2023 - cell.com
Globally, neurological diseases pose a major burden to healthcare professionals in terms of
the management and prevention of the disorder. Among neurological diseases, Alzheimer's …

Biomimetic Nanovesicles as a Dual Gene Delivery System for the Synergistic Gene Therapy of Alzheimer's Disease

S Jiang, G Cai, Z Yang, H Shi, H Zeng, Q Ye, Z Hu… - ACS …, 2024 - ACS Publications
The association between dysfunctional microglia and amyloid-β (Aβ) is a fundamental
pathological event and increases the speed of Alzheimer's disease (AD). Additionally, the …

[HTML][HTML] Advances in the application of extracellular vesicles derived from three-dimensional culture of stem cells

W Chen, P Wu, C Jin, Y Chen, C Li, H Qian - Journal of …, 2024 - Springer
Stem cells (SCs) have been used therapeutically for decades, yet their applications are
limited by factors such as the risk of immune rejection and potential tumorigenicity …