Intrathymic T cell development is a complex process that depends upon continuous
guidance from thymus stromal cell microenvironments. The thymic epithelium within the …

The generation of a functional T cell repertoire in the thymus is mainly orchestrated by
thymic epithelial cells (TECs), which provide developing T cells with cues for their …

A functional immune system requires the selection of T lymphocytes expressing receptors
that are major histocompatibility complex restricted but tolerant to self-antigens. This …

The effects of aging on the immune system are widespread and extend from hematopoietic
stem cells and lymphoid progenitors in the bone marrow and thymus to mature lymphocytes …

It is now becoming apparent that the immune system undergoes age‐associated alterations,
which accumulate to produce a progressive deterioration in the ability to respond to …

Chronic thymus involution associated with aging results in less efficient T-cell development
and decreased emigration of naïve T cells to the periphery. Thymic decline in the aged is …

Proteasomes are responsible for generating peptides presented by the class I major
histocompatibility complex (MHC) molecules of the immune system. Here, we report the …

Recent elucidation of the role of central tolerance in preventing organ-specific autoimmunity
has changed our concepts of self/nonself discrimination. This paradigmatic shift is largely …

The thymus is the primary organ responsible for generating functional T cells in vertebrates.
Although T cell differentiation within the thymus has been an area of intense investigation …

The transcription factor Aire controls immunological tolerance by inducing the ectopic thymic
expression of many tissue-specific genes, acting broadly by removing stops on the …