The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Marginal-Zone Lymphomas The third most common lymphoma, MZL is usually indolent and
often a consequence of chronic antigenic stimulation from a pathogen such as Helicobacter …

Since the publication of the Revised European-American Classification of Lymphoid
Neoplasms in 1994, subsequent updates of the classification of lymphoid neoplasms have …

With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …

The fifth edition of the World Health Organization Classification of Haematolymphoid
Tumours (WHO‐HAEM5) is the product of an evidence‐based evolution of the revised fourth …

Follicular lymphoma (FL) and marginal zone lymphoma (MZL) are indolent mature B-cell
neoplasms with variable clinical presentation and distinct histopathologic features. Recent …

Notch and Hedgehog signaling are involved in cancer biology and pathology, including the
maintenance of tumor cell proliferation, cancer stem-like cells, and the tumor …

Inhibitors of phosphatidylinositol 3-kinase (PI3K) and Bruton tyrosine kinase (BTK) represent
a recognized option for the treatment of patients affected by indolent B cell lymphomas …

Careful histopathologic examination remains the cornerstone in the diagnosis of the
clinically and biologically heterogeneous group of lymphoid malignancies. However, recent …

The genetic mechanisms associated with splenic marginal zone lymphoma (SMZL)
transformation are not well defined. We studied 41 patients with SMZL that eventually …