TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

Before anoctamins (TMEM16 proteins) were identified as a family of Ca2+-activated chloride
channels and phospholipid scramblases, the founding member anoctamin 1 (ANO1 …

Key Points• Chloride channels are important for proper hydration of the airway surface.•
TMEM16A protein is an important component of calcium‐activated chloride channels.• …

The Cl−-transporting proteins CFTR, SLC26A9, and anoctamin (ANO1; ANO6) appear to
have more in common than initially suspected, as they all participate in the pathogenic …

Activation of ion channels and pores are essential steps during regulated cell death.
Channels and pores participate in execution of apoptosis, necroptosis and other forms of …

Abstract Endogenous Ca 2+-activated Cl− channels (CaCC) demonstrate biophysical and
pharmacological properties that are well represented in cells overexpressing anoctamin 1 …

Intestinal epithelial electrolyte secretion is activated by increase in intracellular cAMP or Ca
2+ and opening of apical Cl− channels. In infants and young animals, but not in adults, Ca …

Two genes encode the Na+‐K+‐2Cl− cotransporters, NKCC1 and NKCC2, that mediate the
tightly coupled movement of 1Na+, 1K+, and 2Cl− across the plasma membrane of cells …

Highlights•Fluorometic imaging and microelectrodes allow dynamic assessment of pH
microenvironments.•Transgenic and knockout mice allow delineation of new regulatory …

Background and Purpose The molecular identity of calcium‐activated chloride channels (C
a CC s) in vascular endothelial cells remains unknown. This study sought to identify whether …