Structure and function of TMEM16 proteins (anoctamins)
N Pedemonte, LJV Galietta - Physiological reviews, 2014 - journals.physiology.org
TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …
Contribution of anoctamins to cell survival and cell death
K Kunzelmann, J Ousingsawat, R Benedetto, I Cabrita… - Cancers, 2019 - mdpi.com
Before anoctamins (TMEM16 proteins) were identified as a family of Ca2+-activated chloride
channels and phospholipid scramblases, the founding member anoctamin 1 (ANO1 …
channels and phospholipid scramblases, the founding member anoctamin 1 (ANO1 …
Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia
Key Points• Chloride channels are important for proper hydration of the airway surface.•
TMEM16A protein is an important component of calcium‐activated chloride channels.• …
TMEM16A protein is an important component of calcium‐activated chloride channels.• …
Pathogenic relationships in cystic fibrosis and renal diseases: CFTR, SLC26A9 and anoctamins
K Kunzelmann, J Ousingsawat, A Kraus… - International journal of …, 2023 - mdpi.com
The Cl−-transporting proteins CFTR, SLC26A9, and anoctamin (ANO1; ANO6) appear to
have more in common than initially suspected, as they all participate in the pathogenic …
have more in common than initially suspected, as they all participate in the pathogenic …
Ion channels in regulated cell death
K Kunzelmann - Cellular and Molecular Life Sciences, 2016 - Springer
Activation of ion channels and pores are essential steps during regulated cell death.
Channels and pores participate in execution of apoptosis, necroptosis and other forms of …
Channels and pores participate in execution of apoptosis, necroptosis and other forms of …
Anoctamins
K Kunzelmann, Y Tian, JR Martins, D Faria… - … -European Journal of …, 2011 - Springer
Abstract Endogenous Ca 2+-activated Cl− channels (CaCC) demonstrate biophysical and
pharmacological properties that are well represented in cells overexpressing anoctamin 1 …
pharmacological properties that are well represented in cells overexpressing anoctamin 1 …
Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine
R Schreiber, D Faria, BV Skryabin… - … -European Journal of …, 2015 - Springer
Intestinal epithelial electrolyte secretion is activated by increase in intracellular cAMP or Ca
2+ and opening of apical Cl− channels. In infants and young animals, but not in adults, Ca …
2+ and opening of apical Cl− channels. In infants and young animals, but not in adults, Ca …
Na+‐K+‐2Cl− Cotransporter (NKCC) Physiological Function in Nonpolarized Cells and Transporting Epithelia
Two genes encode the Na+‐K+‐2Cl− cotransporters, NKCC1 and NKCC2, that mediate the
tightly coupled movement of 1Na+, 1K+, and 2Cl− across the plasma membrane of cells …
tightly coupled movement of 1Na+, 1K+, and 2Cl− across the plasma membrane of cells …
Gastrointestinal HCO3− transport and epithelial protection in the gut: new techniques, transport pathways and regulatory pathways
UE Seidler - Current Opinion in Pharmacology, 2013 - Elsevier
Highlights•Fluorometic imaging and microelectrodes allow dynamic assessment of pH
microenvironments.•Transgenic and knockout mice allow delineation of new regulatory …
microenvironments.•Transgenic and knockout mice allow delineation of new regulatory …
Hypoxia augments the calcium‐activated chloride current carried by anoctamin‐1 in cardiac vascular endothelial cells of neonatal mice
MM Wu, J Lou, BL Song, YF Gong, YC Li… - British journal of …, 2014 - Wiley Online Library
Background and Purpose The molecular identity of calcium‐activated chloride channels (C
a CC s) in vascular endothelial cells remains unknown. This study sought to identify whether …
a CC s) in vascular endothelial cells remains unknown. This study sought to identify whether …