Phytochemistry and pharmacology of natural prenylated flavonoids

HW Lv, QL Wang, M Luo, MD Zhu, HM Liang… - Archives of Pharmacal …, 2023 - Springer
Prenylated flavonoids are a special kind of flavonoid derivative possessing one or more
prenyl groups in the parent nucleus of the flavonoid. The presence of the prenyl side chain …

Sophora alopecuroides L.: An ethnopharmacological, phytochemical, and pharmacological review

R Wang, X Deng, Q Gao, X Wu, L Han, X Gao… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Sophora alopecuroides L., which is called Kudouzi in
China, is a medicinal plant distributed in Western and Central Asia, especially in China, and …

[HTML][HTML] Cytoprotective effect of chlorogenic acid against hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells through PI3K/Akt-mediated Nrf2/HO-1 …

D Han, W Chen, X Gu, R Shan, J Zou, G Liu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Osteoporosis is a disorder of bone and its development is closely associated with oxidative
stress and reactive oxygen species (ROS). Chlorogenic acid (CGA) has potential antioxidant …

Xanthatin alleviates LPS-induced inflammatory response in RAW264. 7 macrophages by inhibiting NF-κB, MAPK and STATs activation

Y Liu, W Chen, F Zheng, H Yu, K Wei - Molecules, 2022 - mdpi.com
Xanthatin (XT) is a sesquiterpene lactone isolated from the Chinese herb Xanthium, which
belongs to the Asteraceae family. In this study, we developed an inflammation model via …

Antimycobacterial and Anti-inflammatory Mechanisms of Baicalin via Induced Autophagy in Macrophages Infected with Mycobacterium tuberculosis

Q Zhang, J Sun, Y Wang, W He, L Wang… - Frontiers in …, 2017 - frontiersin.org
Tuberculosis (TB) remains a leading killer worldwide among infectious diseases and the
effective control of TB is still challenging. Autophagy is an intracellular self-digestion process …

Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery

J Li, R Zhao, P Miao, F Xu, J Chen, X Jiang… - European Journal of …, 2023 - Elsevier
Natural products have been utilized for medicinal purposes for millennia, endowing them
with a rich source of chemical scaffolds and pharmacological leads for drug discovery …

Green synthesis of gold nanoparticles using Euphrasia officinalisleaf extract to inhibit lipopolysaccharide-induced inflammation through NF-κB and JAK/STAT …

Y Liu, S Kim, YJ Kim, H Perumalsamy… - International journal …, 2019 - Taylor & Francis
Background Gold nanoparticles (AuNPs) have potential applications in the treatment and
diagnosis process, which are attributed to their biocompatibility and high efficiency of drug …

The pharmacology of the genus Sophora (Fabaceae): An updated review

SH Aly, AM Elissawy, OA Eldahshan, MA Elshanawany… - Phytomedicine, 2019 - Elsevier
Abstract Background The genus Sophora (Fabaceae) represents one of the important
medicinal plant genera regarding its chemical constituents and outstanding …

Therapeutic modulation of JAK-STAT, mTOR, and PPAR-γ signaling in neurological dysfunctions

S Kumar, S Mehan, AS Narula - Journal of Molecular Medicine, 2023 - Springer
The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription
(STAT) cascade is a pleiotropic pathway that involves receptor subunit multimerization. The …

Anti-inflammatory activity of extracts and pure compounds derived from plants via modulation of signaling pathways, especially PI3K/AKT in macrophages

A Merecz-Sadowska, P Sitarek, T Śliwiński… - International journal of …, 2020 - mdpi.com
The plant kingdom is a source of important therapeutic agents. Therefore, in this review, we
focus on natural compounds that exhibit efficient anti-inflammatory activity via modulation …