ABSTRACT GM-CSF was originally defined by its ability to generate in vitro granulocyte and
macrophage colonies from bone marrow precursor cells. Apart from its physiological role in …

The incidence of invasive aspergillosis is markedly increasing, and mortality remains dismal.
Previously there were only 2 antifungals with activity against Aspergillus, but over the last …

Candida glabrata has emerged as an important fungal pathogen of humans, causing life-
threatening infections in immunocompromised patients. In contrast, mice do not develop …

Invasive aspergillosis is a devastating and increasingly common disease, seen almost
exclusively in immunosuppressed patients. Immunizing an immunocompromised host would …

The outcome of the Th1/Th2 balance is a critical determinant of the outcome in invasive
aspergillosis. The innate immune system encounters the pathogen first. Dendritic cells (DC) …

There is substantial evidence that local production of proinflammatory cytokines are very
important in host resistance to aspergillosis. Dexamethasone (DEX) down-regulates …

Background The dexamethasone (DEX) immunosuppressive effect on macrophage killing
activity and cytokine production in response to Aspergillus fumigatus conidia is antagonized …

The immunosuppressive effect of dexamethasone (DEX) on macrophage killing activity and
cytokine production in response to Aspergillus fumigatus conidia is antagonized by …

During the past decade, the rapid growth of molecular and cellular knowledge of
macrophages, as a specialized host defense and homeostatic system, has begun to offer …

Acid-terminated polyglycolide microparticles (PG-MP) were prepared as a versatile
substrate that could be surface-modified for either immobilization of anti-cd3 and anti-cd28 …