Paracrine mechanisms of mesenchymal stromal cells in angiogenesis

S Maacha, H Sidahmed, S Jacob… - Stem cells …, 2020 - Wiley Online Library
The role of the mesenchymal stromal cell‐(MSC‐) derived secretome is becoming
increasingly intriguing from a clinical perspective due to its ability to stimulate endogenous …

Lipid mediated regulation of adult stem cell behavior

M Clémot, R Sênos Demarco, DL Jones - Frontiers in Cell and …, 2020 - frontiersin.org
Adult stem cells constitute an important reservoir of self-renewing progenitor cells and are
crucial for maintaining tissue and organ homeostasis. The capacity of stem cells to self …

The highly unnatural fatty acid profile of cells in culture

PL Else - Progress in lipid research, 2020 - Elsevier
The fatty acid profile of cells in culture are unlike those of natural cells with twice the
monounsaturated (MUFA) and half the polyunsaturated fatty acids (PUFA) level (Mol%). This …

Towards physiologic culture approaches to improve standard cultivation of mesenchymal stem cells

I Nikolits, S Nebel, D Egger, S Kreß, C Kasper - Cells, 2021 - mdpi.com
Mesenchymal stem cells (MSCs) are of great interest for their use in cell-based therapies
due to their multipotent differentiation and immunomodulatory capacities. In consequence of …

Mitigating oxidative stress in perinatal cells: a critical step toward an optimal therapeutic use in regenerative medicine

V Pizzuti, F Paris, P Marrazzo, L Bonsi, F Alviano - Biomolecules, 2023 - mdpi.com
Oxidative stress (OS) occurs when the production of reactive oxygen species (ROS) is not
balanced by the body's antioxidant defense system. OS can profoundly affect cellular health …

A comorbidity model of myocardial ischemia/reperfusion injury and hypercholesterolemia in rat cardiac myocyte cultures

A Makkos, Á Szántai, J Pálóczi, J Pipis, B Kiss… - Frontiers in …, 2020 - frontiersin.org
Introduction The use of comorbidity models is crucial in cardioprotective drug development.
Hypercholesterolemia causes endothelial and myocardial dysfunction, as well as …

[HTML][HTML] Human fetal membrane-mesenchymal stromal cells generate functional spinal motor neurons in vitro

G Gaggi, A Di Credico, S Guarnieri, MA Mariggiò… - Iscience, 2022 - cell.com
Human fetal membrane mesenchymal stromal cells (hFM-MSCs) are a cell population easily
isolable from the amniochorionic membrane of term placentas, without ethical issues or …

Endo-and exometabolome crosstalk in mesenchymal stem cells undergoing osteogenic differentiation

DSC Bispo, L Michálková, M Correia, CSH Jesus… - Cells, 2022 - mdpi.com
This paper describes, for the first time to our knowledge, a lipidome and exometabolome
characterization of osteogenic differentiation for human adipose tissue stem cells (hAMSCs) …

Spare parts from discarded materials: Fetal annexes in regenerative medicine

G Gaggi, P Izzicupo, A Di Credico, S Sancilio… - International Journal of …, 2019 - mdpi.com
One of the main aims in regenerative medicine is to find stem cells that are easy to obtain
and are safe and efficient in either an autologous or allogenic host when transplanted. This …

Epigenetic features of human perinatal stem cells redefine their stemness potential

G Gaggi, A Di Credico, P Izzicupo, I Antonucci… - Cells, 2020 - mdpi.com
Human perinatal stem cells (SCs) can be isolated from fetal annexes without ethical or
safety limitations. They are generally considered multipotent; nevertheless, their biological …