Promises and pitfalls of imaging-based biomarkers in motor neuron diseases
EL Tan, P Bede, PF Pradat - Current Opinion in Neurology, 2023 - journals.lww.com
Although we acknowledge the academic achievements of large descriptive studies, an
unmet priority of neuroimaging in MND is the development of robust diagnostic, prognostic …
unmet priority of neuroimaging in MND is the development of robust diagnostic, prognostic …
Biomarkers in amyotrophic lateral sclerosis: current status and future prospects
Disease heterogeneity in amyotrophic lateral sclerosis poses a substantial challenge in drug
development. Categorization based on clinical features alone can help us predict the …
development. Categorization based on clinical features alone can help us predict the …
Association between brain and upper cervical spinal cord atrophy assessed by MRI and disease aggressiveness in amyotrophic lateral sclerosis
MM El Mendili, A Verschueren, JP Ranjeva, M Guye… - Neuroradiology, 2023 - Springer
Purpose To study the relative contributions of brain and upper cervical spinal cord
compartmental atrophy to disease aggressiveness in amyotrophic lateral sclerosis (ALS) …
compartmental atrophy to disease aggressiveness in amyotrophic lateral sclerosis (ALS) …
Imaging extra-motor dysfunction in motor neuron disease: achievements and controversies
P Bede, RH Chipika, EL Tan - Amyotrophic Lateral Sclerosis and …, 2023 - Taylor & Francis
There is an ever growing literature on frontotemporal dysfunction in motor neuron diseases,
but the practical caveats of using imaging to evaluate extra-motor changes and linking …
but the practical caveats of using imaging to evaluate extra-motor changes and linking …
The gap between academic advances and therapy development in motor neuron disease
P Bede, PF Pradat - Current Opinion in Neurology, 2023 - journals.lww.com
Despite the universal recognition of the fundamental clinical, genetic and pathological
heterogeneity of amyotrophic lateral sclerosis (ALS), the expectation that the same drug may …
heterogeneity of amyotrophic lateral sclerosis (ALS), the expectation that the same drug may …
Mismatch between clinically defined classification of ALS stage and the burden of cerebral pathology
P Parnianpour, M Benatar, H Briemberg, A Dey… - Journal of …, 2024 - Springer
This study aimed to investigate the clinical stratification of amyotrophic lateral sclerosis
(ALS) patients in relation to in vivo cerebral degeneration. One hundred forty-nine ALS …
(ALS) patients in relation to in vivo cerebral degeneration. One hundred forty-nine ALS …
The involvement of language‐associated networks, tracts, and cortical regions in frontotemporal dementia and amyotrophic lateral sclerosis: Structural and functional …
M Tahedl, EL Tan, RH Chipika, J Lope… - Brain and …, 2023 - Wiley Online Library
Background Language deficits are cardinal manifestations of some frontotemporal dementia
(FTD) phenotypes and also increasingly recognized in sporadic and familial amyotrophic …
(FTD) phenotypes and also increasingly recognized in sporadic and familial amyotrophic …
[HTML][HTML] Harnessing Big Data in Amyotrophic Lateral Sclerosis: Machine Learning Applications for Clinical Practice and Pharmaceutical Trials
EL Tan, J Lope, P Bede - Journal of Integrative Neuroscience, 2024 - imrpress.com
The arrival of genotype-specific therapies in amyotrophic lateral sclerosis (ALS) signals the
dawn of precision medicine in motor neuron diseases (MNDs). After decades of academic …
dawn of precision medicine in motor neuron diseases (MNDs). After decades of academic …
Graph network measures reveal distinct white matter abnormalities in motor and extra-motor brain regions of two UMN-predominant ALS subtypes
V Rajagopalan, EP Pioro - Journal of the Neurological Sciences, 2023 - Elsevier
Background Routine clinical magnetic resonance imaging (MRI) shows bilateral
corticospinal tract (CST) hyperintensity in some patients with upper motor neuron (UMN) …
corticospinal tract (CST) hyperintensity in some patients with upper motor neuron (UMN) …