Hypertension is characterized by structural and functional changes in blood vessels that
travel with increased arterial stiffness, vascular inflammation, and endothelial dysfunction …

In recent years, much interest has been generated by the idea that nitrosative stress plays a
role in the aetiology of human diseases, such as atherosclerosis, inflammation, cancer, and …

A large body of evidence indicates that patients with essential hypertension are
characterized by endothelial dysfunction mediated by an impaired NO availability secondary …

Within the family of endogenous gasotransmitters, nitric oxide (NO) is the smallest gaseous
intercellular messenger involved in the modulation of several processes, such as blood flow …

Although well established in treating hypertension and cardiovascular (CV) disease, clinical
trial data suggest that β-blockers (eg, atenolol) may be less effective than other …

High level of circulating red cell distribution width (RDW) and neutrophil/lymphocyte (N/L)
ratio may reflect ongoing vascular inflammation and play an important role in …

Background. Altered renal vasodilatation and oxidative stress are important mechanisms of
contrast-induced nephropathy (CIN). The aim of the present study was to assess the effect of …

Endothelial dysfunction is a systemic pathological state of the endothelium characterized by
a reduction in the bioavailability of vasodilators, essentially nitric oxide, leading to impaired …

Nebivolol (Bystolic®) is a cardioselective beta 1 (β1)‐adrenergic receptor blocker with
endothelium‐dependent vasodilating properties. The endothelium‐dependent relaxation …

The third generation β-blockers possess important ancillary properties besides inhibiting β-
adrenoceptors. Among them, nebivolol activates nitric oxide synthase (NOS). Nebivolol and …