Non-coding RNAs and potential therapeutic targeting in cancer

S Toden, TJ Zumwalt, A Goel - … et Biophysica Acta (BBA)-Reviews on …, 2021 - Elsevier
Recent advances have begun to clarify the physiological and pathological roles of non-
coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs …

Long non-coding RNAs in cancer: implications for diagnosis, prognosis, and therapy

Y Qian, L Shi, Z Luo - Frontiers in medicine, 2020 - frontiersin.org
Long non-coding RNAs (lncRNAs) are major components of cellular transcripts that are
arising as important players in various biological pathways. They have received extensive …

Potential of long non‐coding RNAs in cancer patients: from biomarkers to therapeutic targets

S Chandra Gupta… - International journal of …, 2017 - Wiley Online Library
Because of high specificity and easy detection in the tissues, serum, plasma, urine and
saliva, interest in exploring the potential of long non‐coding RNAs (lncRNAs) in cancer …

Non-coding RNAs: the new central dogma of cancer biology

PE Saw, X Xu, J Chen, EW Song - Science China Life Sciences, 2021 - Springer
The central dogma of molecular biology states that the functions of RNA revolve around
protein translation. Until the last decade, most researches were geared towards …

From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis

S Dhamija, S Diederichs - International journal of cancer, 2016 - Wiley Online Library
Metastasis is a multistep process that involves the dissemination of cells from the primary
tumor and colonization of distant secondary organs. Epithelial cells at the invasive front of a …

Emerging role of oncogenic long noncoding RNA as cancer biomarkers

M Aprile, V Costa, A Cimmino… - International journal of …, 2023 - Wiley Online Library
The view of long noncoding RNAs as nonfunctional “garbage” has been definitely outdated
by the large body of evidence indicating this class of ncRNAs as “golden junk”, especially in …

A novel mechanism of lncRNA and miRNA interaction: CCAT2 regulates miR-145 expression by suppressing its maturation process in colon cancer cells

Y Yu, P Nangia-Makker, L Farhana, APN Majumdar - Molecular cancer, 2017 - Springer
Background Although both long and micro RNAs are emerging as important functional
components in colorectal cancer (CRC) progression and metastasis, the mechanism of their …

Long non-coding RNAs: key regulators of epithelial-mesenchymal transition, tumour drug resistance and cancer stem cells

R Heery, SP Finn, S Cuffe, SG Gray - Cancers, 2017 - mdpi.com
Epithelial mesenchymal transition (EMT), the adoption by epithelial cells of a mesenchymal-
like phenotype, is a process co-opted by carcinoma cells in order to initiate invasion and …

CDKN2B-AS1 as a novel therapeutic target in cancer: Mechanism and clinical perspective

A Hjazi, E Ghaffar, W Asghar, HA Khalaf… - Biochemical …, 2023 - Elsevier
Long non-coding RNAs (lncRNA) have been identified as essential components having
considerable modulatory impacts on biological activities through altering gene transcription …

Targeting long non-coding RNAs in cancer therapy using CRISPR-Cas9 technology: a novel paradigm for precision oncology

RK Mahato, S Bhattacharya, N Khullar, IS Sidhu… - Journal of …, 2023 - Elsevier
Cancer is the second leading cause of death worldwide, despite recent advances in its
identification and management. To improve cancer patient diagnosis and care, it is …