Inhibiting sexual transmission of HIV-1 infection

RJ Shattock, JP Moore - Nature Reviews Microbiology, 2003 - nature.com
The worldwide infection rate for HIV-1 is estimated to be 14,000 per day, but only now, more
than 20 years into the epidemic, are the immediate events between exposure to infectious …

Microbicide drug candidates to prevent HIV infection

J Balzarini, L Van Damme - The Lancet, 2007 - thelancet.com
Summary 25 years after the first HIV/AIDS cases emerged in 1981, the disease continues to
spread worldwide, with about 15 000 new infections every day. Although highly active …

Antiretroviral activity of the anti-CD4 monoclonal antibody TNX-355 in patients infected with HIV type 1

DR Kuritzkes, J Jacobson, WG Powderly… - The Journal of …, 2004 - academic.oup.com
Background We wished to determine the safety and anti–human immunodeficiency virus
(HIV) type 1 activity of single doses of TNX-355, a humanized IgG4 anti-CD4 monoclonal …

[HTML][HTML] The antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro

C Lorin, H Saidi, A Belaid, A Zairi, F Baleux, H Hocini… - Virology, 2005 - Elsevier
Most of HIV-1 infections are acquired through sexual contact. In the absence of a preventive
vaccine, the development of topical microbicides that can block infection at the mucosal …

[HTML][HTML] Ibalizumab targeting CD4 receptors, an emerging molecule in HIV therapy

SA Iacob, DG Iacob - Frontiers in microbiology, 2017 - frontiersin.org
The HIV infection is responsible for the most devastating global pandemic of the last century.
More than 39 million people have died of HIV/AIDS since 1981. The development of the …

[PDF][PDF] Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody

MM Freeman, MS Seaman, S Rits-Volloch, X Hong… - Structure, 2010 - cell.com
Ibalizumab is a humanized, anti-CD4 monoclonal antibody. It potently blocks HIV-1 infection
and targets an epitope in the second domain of CD4 without interfering with immune …

CADA, a novel CD4-targeted HIV inhibitor, is synergistic with various anti-HIV drugs in vitro

K Vermeire, K Princen, S Hatse, E De Clercq, K Dey… - Aids, 2004 - journals.lww.com
Objective: To evaluate the anti-HIV-1 activity of the cyclotriazadisulfonamide CADA against
primary isolates in vitro and the combination of CADA with approved anti-HIV drugs for …

Ibalizumab: an anti-CD4 monoclonal antibody for the treatment of HIV-1 infection

CJ Bruno, JM Jacobson - Journal of antimicrobial chemotherapy, 2010 - academic.oup.com
The majority of currently available agents for the treatment of HIV-1 infection act by targeting
one of several intracellular steps in the viral life cycle. Despite improvements in efficacy and …

The appealing story of HIV entry inhibitors: from discovery of biological mechanisms to drug development

A Castagna, P Biswas, A Beretta, A Lazzarin - Drugs, 2005 - Springer
Current therapeutic intervention in HIV infection relies upon 20 different drugs. Despite the
impressive efficacy shown by these drugs, we are confronted with an unexpected frequency …

Novel human antibody therapeutics: the age of the Umabs

SR Ruuls, JJ Lammerts van Bueren… - Biotechnology …, 2008 - Wiley Online Library
Monoclonal antibodies represent a major and increasingly important category of
biotechnology products for the treatment of human diseases. The state‐of‐the‐art of …