Review of the endocannabinoid system
The endocannabinoid system (ECS) is a widespread neuromodulatory network involved in
the developing central nervous system as well as playing a major role in tuning many …
the developing central nervous system as well as playing a major role in tuning many …
Cannabidiol adverse effects and toxicity
MA Huestis, R Solimini, S Pichini… - Current …, 2019 - ingentaconnect.com
Background: Currently, there is a great interest in the potential medical use of cannabidiol
(CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD …
(CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD …
In vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa
The Cannabis sativa plant contains more than 120 cannabinoids. With the exceptions of∆ 9-
tetrahydrocannabinol (∆ 9-THC) and cannabidiol (CBD), comparatively little is known about …
tetrahydrocannabinol (∆ 9-THC) and cannabidiol (CBD), comparatively little is known about …
Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol‐dimethylheptyl at the type 1 and type 2 cannabinoid receptors
M Tham, O Yilmaz, M Alaverdashvili… - British journal of …, 2019 - Wiley Online Library
Background and Purpose We sought to understand why (−)‐cannabidiol (CBD) and (−)‐
cannabidiol‐dimethylheptyl (CBD‐DMH) exhibit distinct pharmacology, despite near …
cannabidiol‐dimethylheptyl (CBD‐DMH) exhibit distinct pharmacology, despite near …
THC and CBD: Similarities and differences between siblings
N Stella - Neuron, 2023 - cell.com
Summary Δ 9-tetrahydrocannabinol (THC) and its sibling, cannabidiol (CBD), are produced
by the same Cannabis plant and have similar chemical structures but differ dramatically in …
by the same Cannabis plant and have similar chemical structures but differ dramatically in …
[HTML][HTML] Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity
EC Rosenberg, S Chamberland, M Bazelot, ER Nebet… - Neuron, 2023 - cell.com
Summary Cannabidiol (CBD), a non-euphoric component of cannabis, reduces seizures in
multiple forms of pediatric epilepsies, but the mechanism (s) of anti-seizure action remain …
multiple forms of pediatric epilepsies, but the mechanism (s) of anti-seizure action remain …
Therapeutic and clinical foundations of cannabidiol therapy for difficult-to-treat seizures in children and adults with refractory epilepsies
DS Reddy - Experimental neurology, 2023 - Elsevier
Novel and effective antiseizure medications are needed to treat refractory and rare forms of
epilepsy. Cannabinoids, which are obtained from the cannabis plant, have a long history of …
epilepsy. Cannabinoids, which are obtained from the cannabis plant, have a long history of …
Inhibitory effects of cannabidiol on voltage-dependent sodium currents
MR Ghovanloo, NG Shuart, J Mezeyova… - Journal of Biological …, 2018 - ASBMB
Cannabis sativa contains many related compounds known as phytocannabinoids. The main
psychoactive and nonpsychoactive compounds are Δ9-tetrahydrocannabinol (THC) and …
psychoactive and nonpsychoactive compounds are Δ9-tetrahydrocannabinol (THC) and …
A randomised controlled trial of vaporised Δ9-tetrahydrocannabinol and cannabidiol alone and in combination in frequent and infrequent cannabis users: acute …
N Solowij, S Broyd, L Greenwood, H van Hell… - European archives of …, 2019 - Springer
Access to cannabis and cannabinoid products is increasing worldwide for recreational and
medicinal use. Two primary compounds within cannabis plant matter, Δ 9 …
medicinal use. Two primary compounds within cannabis plant matter, Δ 9 …
The endocannabinoid system and cannabidiol's promise for the treatment of substance use disorder
Substance use disorder is characterized by repeated use of a substance, leading to
clinically significant distress, making it a serious public health concern. The …
clinically significant distress, making it a serious public health concern. The …