Paeoniflorin attenuates myocardial fibrosis in isoprenaline-induced chronic heart failure rats via inhibiting P38 MAPK pathway

M Liu, J Feng, Q Du, J Ai, Z Lv - Current Medical Science, 2020 - Springer
Paeoniforin (Pae) is a monoterpenoid glycoside compound and has many biological
activities, such as immunosuppression, anti-inflammation and anti-cell proliferation …

Paeoniflorin inhibits human pancreatic cancer cell apoptosis via suppression of MMP-9 and ERK signaling

N Yang, H Cui, F Han, L Zhang, T Huang… - Oncology …, 2016 - spandidos-publications.com
Paeoniflorin exhibits anticancer, anti-inflammatory and antioxidation effects, as well as
specific pharmacological effects on smooth muscle and the immune, cardiovascular and …

Panax ginseng CA Meyer as a potential therapeutic agent for organ fibrosis disease

H Liu, C Lv, J Lu - Chinese Medicine, 2020 - Springer
Abstract Background Ginseng (Panax ginseng CA Meyer), a representative Chinese herbal
medicine, can improve the body's antioxidant and anti-inflammatory capacity. Recently …

Paeoniflorin alleviates NG-nitro-L-arginine methyl ester (L-NAME)-induced gestational hypertension and upregulates silent information regulator 2 related enzyme 1 …

J Wu, D Zhang, L Hu, X Zheng, C Chen - Bioengineered, 2022 - Taylor & Francis
Pregnancy-induced hypertension (PIH) is a leading cause of maternal mortality. Paeoniflorin
has been reported to alleviate hypertension, thus relieving the injury of target organ. This …

Paeoniflorin inhibits PDGF‑BB‑induced human airway smooth muscle cell growth and migration

H Zhou, Q Wu, L Wei, S Peng - Molecular Medicine …, 2018 - spandidos-publications.com
Abnormal proliferation and migration of airway smooth muscle cells (ASMCs) is important in
the progression of asthma. Paeoniflorin (PF), one of the major active ingredients of Paeonia …

[HTML][HTML] Effect of paeoniflorin on cardiac remodeling in chronic heart failure rats through the transforming growth factor β1/Smad signaling pathway

M Liu, J Ai, J Feng, J Zheng, K Tang… - … diagnosis and therapy, 2019 - ncbi.nlm.nih.gov
Background Cardiac remodeling is an important mechanism for the occurrence and
development of chronic heart failure (CHF). Paeoniflorin (Pae) is the main active ingredient …

[HTML][HTML] Inhibitory effects of total ginsenoside on bleomycin-induced pulmonary fibrosis in mice

L Yang, P Chen, M Luo, W Shi, D Hou, Y Gao… - Biomedicine & …, 2019 - Elsevier
Pulmonary fibrosis is the final outcome of a variety of diffuse pulmonary interstitial diseases,
and it has an unclear pathogenesis. There is no effective drug treatment, so the clinical …

The therapeutic mechanism of Schisandrol A and its metabolites on pulmonary fibrosis based on plasma metabonomics and network analysis

X Qiaolongbatu, W Zhao, X Huang, F Qian… - Drug Design …, 2023 - Taylor & Francis
Background Schisandrol A (Sch A) is the main active ingredient of Schisandra chinensis
(Turcz.) Baill. Our previous study showed that Sch A has anti-pulmonary fibrosis (PF) activity …

Imrecoxib Inhibits Paraquat‐Induced Pulmonary Fibrosis through the NF‐κB/Snail Signaling Pathway

H Jin - Computational and Mathematical Methods in Medicine, 2020 - Wiley Online Library
Objective. In recent years, pulmonary fibrosis caused by paraquat poisoning is still
concerned. However, no effective drugs have been developed yet to treat paraquat‐induced …

Trimetazidine Alleviates Bleomycin-Induced Pulmonary Fibrosis by Targeting the Long Noncoding RNA CBR3-AS1-Mediated miRNA-29 and Resistin-Like Molecule …

AR Alzahrani, DI Mohamed… - Drug Design …, 2024 - Taylor & Francis
Introduction Pulmonary fibrosis (PF) and tissue remodeling can greatly impair pulmonary
function and often lead to fatal outcomes. Methodology In the present study, we explored a …