Micro-and nanoplastics (MNPs) are recognized as emerging contaminants, especially in
food, with unknown health significance. MNPs passing through the gastrointestinal tract …

Novel immune checkpoint blockade with ipilimumab, an antibody blocking the cytotoxic T-
lymphocyte antigen 4 (CTLA4), is revolutionizing cancer therapy. However, ipilimumab …

By eliciting distinct transcriptional responses, the oestrogen receptors (ERs) ERα and ERβ
exert opposite effects on cellular processes that include proliferation, apoptosis and …

In recent years, nutraceuticals have gained great popularity, owing to their physiological and
potential health effects, such as anti-inflammatory, anti-cancer, antioxidant, and prebiotic …

Estrogens influence many physiological processes in mammals, including but not limited to
reproduction, cardiovascular health, bone integrity, cognition, and behavior. Given this …

17β-Estradiol (E2) controls many aspects of human physiology, including development,
reproduction and homeostasis, through regulation of the transcriptional activity of its cognate …

Lignans are present in a wide range of foods consumed daily in the Western world such as
flaxseed and other seeds, as well as vegetables, fruits and beverages such as coffee, tea …

Upon binding their cognate receptors, ERα (ESR1) and ERβ (ESR2), estrogens activate
intracellular signaling cascades that have important consequences for cellular behavior …

Worldwide, colorectal cancer has a higher incidence rate in men than in women, suggesting
a protective role for sex hormones in the development of the disease. Preclinical data …

Colorectal cancer (CRC) is a leading cause of death in the United States. Despite its slow
development and the capacity for early diagnosis, current preventive approaches are not …