This review compares the biological and physiological function of Sigma receptors [σRs] and
their potential therapeutic roles. Sigma receptors are widespread in the central nervous …

The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …

Progesterone-receptor membrane component 1 (PGRMC1/Sigma-2 receptor) is a haem-
containing protein that interacts with epidermal growth factor receptor (EGFR) and …

Amyloid beta (Abeta) 1–42 oligomers accumulate in brains of patients with Mild Cognitive
Impairment (MCI) and disrupt synaptic plasticity processes that underlie memory formation …

Sigma receptors (sigma-1 and sigma-2) represent two independent classes of proteins.
Their endogenous ligands may include the hallucinogen N, N-dimethyltryptamine (DMT) …

Progesterone receptor membrane component 1 (PGRMC1) is a multi-functional protein with
a heme-binding moiety related to that of cytochrome b 5, which is a putative progesterone …

The σ2 receptor is an important target for the development of molecular probes in oncology
because of its 10-fold higher density in proliferating tumor cells compared with that in …

Background Increased expression of the progesterone receptor membrane component 1
(PGRMC1) has been linked to multiple cancers, including breast cancer. Despite being a …

Autophagy, a cellular recycling process responsible for turnover of cytoplasmic contents, is
critical for maintenance of health. Defects in this process have been linked to diabetes …

The sigma‐2 receptor is highly expressed in various rapidly proliferating cancer cells and
regarded as a cancer cell biomarker. Selective sigma‐2 ligands have been shown to …