[HTML][HTML] Advances in our understanding of oxylipins derived from dietary PUFAs
M Gabbs, S Leng, JG Devassy, M Monirujjaman… - Advances in …, 2015 - Elsevier
Oxylipins formed from polyunsaturated fatty acids (PUFAs) are the main mediators of PUFA
effects in the body. They are formed via cyclooxygenase, lipoxygenase, and cytochrome …
effects in the body. They are formed via cyclooxygenase, lipoxygenase, and cytochrome …
Arachidonic acid metabolism in health and disease
Y Zhang, Y Liu, J Sun, W Zhang, Z Guo, Q Ma - MedComm, 2023 - Wiley Online Library
Arachidonic acid (AA), an n‐6 essential fatty acid, is a major component of mammalian cells
and can be released by phospholipase A2. Accumulating evidence indicates that AA plays …
and can be released by phospholipase A2. Accumulating evidence indicates that AA plays …
[HTML][HTML] Arachidonic acid cytochrome P450 epoxygenase pathway
AA Spector - Journal of lipid research, 2009 - ASBMB
Cytochrome P450 (CYP) epoxygenases convert arachidonic acid to four
epoxyeicosatrienoic acid (EET) regioisomers, 5, 6-, 8, 9-, 11, 12-, and 14, 15-EET, that …
epoxyeicosatrienoic acid (EET) regioisomers, 5, 6-, 8, 9-, 11, 12-, and 14, 15-EET, that …
The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases
X Xu, XA Zhang, DW Wang - Advanced drug delivery reviews, 2011 - Elsevier
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active
eicosanoids. The primary epoxidation products are four regioisomers of cis …
eicosanoids. The primary epoxidation products are four regioisomers of cis …
The athlete's heart vs. the failing heart: can signaling explain the two distinct outcomes?
KL Weeks, JR McMullen - Physiology, 2011 - journals.physiology.org
Cardiac remodeling is typically associated with disease and can lead to heart failure. In
contrast, remodeling that occurs in the athlete's heart is considered an adaptive …
contrast, remodeling that occurs in the athlete's heart is considered an adaptive …
Glucagon-like peptide (GLP)-1 (9-36) amide-mediated cytoprotection is blocked by exendin (9-39) yet does not require the known GLP-1 receptor
The widely expressed dipeptidyl peptidase-4 enzyme rapidly cleaves the gut hormone
glucagon-like peptide-1 [GLP-1 (7-36) amide] at the N terminus to generate GLP-1 (9-36) …
glucagon-like peptide-1 [GLP-1 (7-36) amide] at the N terminus to generate GLP-1 (9-36) …
Cytochrome P450–dependent metabolism of ω-6 and ω-3 long-chain polyunsaturated fatty acids
C Arnold, A Konkel, R Fischer, WH Schunck - Pharmacological Reports, 2010 - Elsevier
Dietary fish oil ω-3 fatty acids (n-3 PUFAs), such as eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA), protect against arrhythmia and sudden cardiac death using …
docosahexaenoic acid (DHA), protect against arrhythmia and sudden cardiac death using …
Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation
The cytochrome P450 (CYP) epoxygenase enzymes CYP2J and CYP2C catalyze the
epoxidation of arachidonic acid to epoxyeicosatrienoic acids (EETs), which are rapidly …
epoxidation of arachidonic acid to epoxyeicosatrienoic acids (EETs), which are rapidly …
Cytochrome P450-derived eicosanoids and heart function
KL Jamieson, T Endo, AM Darwesh… - Pharmacology & …, 2017 - Elsevier
The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of
enzymes, which are important in the metabolism of foreign and endogenous compounds …
enzymes, which are important in the metabolism of foreign and endogenous compounds …
[HTML][HTML] The role of epoxyeicosatrienoic acids in cardiac remodeling
J Lai, C Chen - Frontiers in physiology, 2021 - frontiersin.org
Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by cytochrome P450
(CYP) epoxygenases, which include four regioisomers: 5, 6-EET, 8, 9-EET, 11, 12-EET, and …
(CYP) epoxygenases, which include four regioisomers: 5, 6-EET, 8, 9-EET, 11, 12-EET, and …