The widespread expression of circular RNAs (circRNAs) is regarded as a feature of gene
expression in highly diverged eukaryotes. Recent studies have shown that circRNAs can act …

Neurodegeneration is a leading cause of death in the developed world and a natural, albeit
unfortunate, consequence of longer-lived populations. Despite great demand for therapeutic …

RNA-binding proteins play crucial roles in the regulation of gene expression, and
understanding the interactions between RNAs and RBPs in distinct cellular conditions forms …

Circular RNAs (circRNAs) are non-coding RNAs with a special circular structure produced
formed by the reverse splicing mechanism. Increasing evidence shows that circular RNAs …

Fused in sarcoma (FUS) is a ubiquitously expressed RNA‐binding protein proposed to
function in various RNA metabolic pathways, including transcription regulation, pre‐mRNA …

RNA-binding proteins (RBPs) acting at various steps in the post-transcriptional regulation of
gene expression play crucial roles in neuronal development and synaptic plasticity. Genetic …

Highlights•RNA-seq is emerging as a powerful technology to study alternative splicing.•RNA
mis-splicing can cause cancers and a variety of other human diseases.•To target alternative …

Aging represents the major risk factor for the onset and/or progression of various disorders
including neurodegenerative diseases, metabolic disorders, and bone-related defects. As …

A remarkable post-transitional modification of both histones and non-histone proteins is
arginine methylation. Methylation of arginine residues is crucial for a wide range of cellular …

Alzheimer's disease (AD) is a heterogeneous neurodegenerative disorder and represents
the most common form of senile dementia. The pathogenesis of AD is not yet completely …