Bufalin for an innovative therapeutic approach against cancer

L Soumoy, GE Ghanem, S Saussez, F Journe - Pharmacological Research, 2022 - Elsevier
Bufalin is an endogenous cardiotonic steroid, first discovered in toad venom but also found
in the plasma of healthy humans, with anti-tumour activities in different cancer types. The …

Toad venom: A comprehensive review of chemical constituents, anticancer activities, and mechanisms

FJ Li, JH Hu, X Ren, CM Zhou, Q Liu… - Archiv der …, 2021 - Wiley Online Library
Toad venom, a traditional natural medicine, has been used for hundreds of years in China
for treating different diseases. Many studies have been performed to elucidate the …

Anticancer and antiviral properties of cardiac glycosides: a review to explore the mechanism of actions

D Reddy, R Kumavath, D Barh, V Azevedo, P Ghosh - Molecules, 2020 - mdpi.com
Cardiac glycosides (CGs) have a long history of treating cardiac diseases. However, recent
reports have suggested that CGs also possess anticancer and antiviral activities. The …

New therapeutic aspects of steroidal cardiac glycosides: the anticancer properties of Huachansu and its main active constituent Bufalin

C Cheng, J Wang, J Chen, KT Kuo, J Tang… - Cancer Cell …, 2019 - Springer
Aim of the review In the past decade, increasing research attention investigated the novel
therapeutic potential of steroidal cardiac glycosides in cancer treatment. Huachansu and its …

Therapeutic potential of targeting membrane-spanning proteoglycan SDC4 in hepatocellular carcinoma

H Yang, Y Liu, MM Zhao, Q Guo, XK Zheng, D Liu… - Cell Death & …, 2021 - nature.com
Abstract Syndecan-4 (SDC4) functions as a major endogenous membrane-associated
receptor and widely regulates cytoskeleton, cell adhesion, and cell migration in human …

Chinese medicines for prevention and treatment of human hepatocellular carcinoma: current progress on pharmacological actions and mechanisms

X Wang, N Wang, F Cheung, L Lao, C Li… - Journal of integrative …, 2015 - Elsevier
Hepatocellular carcinoma (HCC) is one of leading causes of death in the world. Although
various treatments have been developed, the therapeutic side effects are far from desirable …

[HTML][HTML] Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1α via the PI3K/AKT/mTOR pathway

H Wang, C Zhang, L Xu, K Zang, Z Ning, F Jiang… - Oncotarget, 2016 - ncbi.nlm.nih.gov
It has been reported that there are multiple mechanisms by which bufalin could exert its
antimetastatic effect. HIF-1α has been reported to be involved in tumor migration and …

A green approach for enhancing oxidation stability including long storage periods of biodiesel via Thuja oreantalis L. as an antioxidant additive

A Devi, VK Das, D Deka - Fuel, 2019 - Elsevier
In this study, we evaluated leaf extract of Thuja oreantalis L. as a natural antioxidant additive
for biodiesel oxidation stability enhancement. Primarily the total phenolic content has been …

Prospects and therapeutic applications of cardiac glycosides in cancer remediation

JI Ayogu, AS Odoh - ACS Combinatorial Science, 2020 - ACS Publications
Active metabolites from natural sources are the predominant molecular targets in numerous
biological studies owing to their appropriate compatibility with biological systems and …

Recent progress in understanding the action of natural compounds at novel therapeutic drug targets for the treatment of liver cancer

Y Zheng, W Zhang, L Xu, H Zhou, M Yuan… - Frontiers in …, 2022 - frontiersin.org
Liver cancer is the third most common cause of cancer-related death following lung and
stomach cancers. As a highly lethal disease, liver cancer is diagnosed frequently in less …