Embryo implantation in the laboratory: an update on current techniques

S Ojosnegros, A Seriola, AL Godeau… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND The embryo implantation process is crucial for the correct establishment
and progress of pregnancy. During implantation, the blastocyst trophectoderm cells attach to …

Identifying biomarkers for predicting successful embryo implantation: applying single to multi-OMICs to improve reproductive outcomes

P Hernández-Vargas, M Muñoz… - Human reproduction …, 2020 - academic.oup.com
BACKGROUND Successful embryo implantation is a complex process that requires the
coordination of a series of events, involving both the embryo and the maternal endometrium …

[HTML][HTML] Creating mini-pregnancy models in vitro with clinical perspectives

JY Park, H Lim, J Qin, LP Lee - EBioMedicine, 2023 - thelancet.com
During the last decade, organs-on-chips or organoids microphysiological analysis platforms
(MAP) have garnered attention in the practical applications of disease models, drug …

Rapid generation of functional nanovesicles from human trophectodermal cells for embryo attachment and outgrowth

QH Poh, A Rai, M Pangestu, LA Salamonsen… - …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are important mediators of embryo attachment and outgrowth
critical for successful implantation. While EVs have garnered immense interest in their …

Annexin A2 acts as an adherent molecule under the regulation of steroids during embryo implantation

B Wang, Y Shao - Molecular human reproduction, 2020 - academic.oup.com
We previously showed that annexin A2 (Axna2) was transiently expressed at the embryo-
uterine luminal epithelium interface during the window of implantation and was involved in …

[HTML][HTML] Association of the Cumulative Live Birth Rate with the Factors in Assisted Reproductive Technology: A Retrospective Study of 16,583 Women

Q Wang, D Qi, L Zhang, J Wang, Y Du, H Lv… - Journal of Clinical …, 2023 - mdpi.com
The cumulative live birth rate (CLBR) can better reflect the overall treatment effect by
successive treatments, and continuous rather than categorical variables as exposure …

miR-149-PARP-2 signaling regulates E-cadherin and N-cadherin expression in the murine model of endometrium receptivity

RK Verma, UK Soni, SB Chadchan, VK Maurya… - Reproductive …, 2022 - Springer
Cadherins play an essential role in the attachment of the blastocyst to the endometrium, a
process known as endometrial receptivity. Loss of E-cadherin expression is essential during …

Bioengineered microphysiological placental models: towards improving understanding of pregnancy health and disease

M Winter, T Jankovic-Karasoulos, CT Roberts… - Trends in …, 2021 - cell.com
Driven by a lack of appropriate human placenta models, recent years have seen the
introduction of bioengineered in vitro models to better understand placental health and …

Beyond 2D: Novel biomaterial approaches for modeling the placenta

SG Zambuto, AK Scott, ML Oyen - Placenta, 2024 - Elsevier
This review considers fully three-dimensional biomaterial environments of varying
complexity as these pertain to research on the placenta. The developments in placental cell …

HB‐EGF‐loaded nanovesicles enhance trophectodermal spheroid attachment and invasion

QH Poh, A Rai, J Cross, DW Greening - Proteomics, 2024 - Wiley Online Library
The ability of trophectodermal cells (outer layer of the embryo) to attach to the endometrial
cells and subsequently invade the underlying matrix are critical stages of embryo …