Interleukin 1-α and tumor necrosis factor-α induce oxygen radical production in mesangial
cells. Adherent human mesangial cells (HMC) were unable to phagocytose serum-treated …

Transforming growth factor-β regulates production of proteoglycans by mesangial cells.
Accumulation of glomerular extracellular matrix is a prominent feature of most forms of …

There is much interest in defining the signals that initiate abnormal proliferation of cells in a
variety of states characterized by the presence of mononuclear phagocytes. Since IL-1 is a …

Proteins undergo a series of nonenzymatic reactions with glucose over time to form
advanced glycosylation end products (AGEs). Macrophages have a receptor that recognizes …

Glomerular accumulation of extracellular matrix is a prominent feature of progressive
glomerulonephritis. Previously, we have shown that transforming growth factor-beta (TGF …

In situ production of TNF-α, IL-1β and IL-2 receptors in ANCA-positive glomerulonephritis.
Humoral and cellular immune mechanisms are thought to be involved in various forms of …

A recently described peptide hormone, endothelin, is a potent vasoconstrictor, but it is
unclear whether endothelin has other biological actions. These experiments extend the …

Francesco S. di Giovine and Gordon W. Duff to one (in fact two) protein (s). Now we have the
reverse situation-many distinct protein entities with specific membrane receptors all …

Puumala hantavirus-induced nephropathia epidemica (NE) is an important cause of an
acute reversible renal failure in Scandinavia, European Russia, and the Balkans. The …

Numerous experimental studies point to the potential role of cytokines and growth factors in
the pathogenesis of renal disease. However, from the various autocrine and paracrine …