Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

The brain has almost no energy reserve, but its activity coordinates organismal function, a
burden that requires precise coupling between neurotransmission and energy metabolism …

Psychiatric disorders encompass complex aberrations of cognition and affect and are
among the most debilitating and poorly understood of any medical condition. Current …

The brain is characterized by heterogeneous patterns of structural connections supporting
unparalleled feats of cognition and a wide range of behaviours. New non-invasive imaging …

The energy demands of the brain are high: they account for at least 20% of the body's
energy consumption. Evolutionary studies indicate that the emergence of higher cognitive …

Imaging of small animals has played an indispensable role in preclinical research by
providing high-dimensional physiological, pathological and phenotypic insights with clinical …

The classroom is an emotional place. The countless hours students spend attending class,
completing projects, taking exams, and building social relationships translate into progress …

Functional magnetic resonance imaging (fMRI) provides a unique view of the working
human mind. The blood-oxygen-level-dependent (BOLD) signal, detected in fMRI, reflects …

A baseline or control state is fundamental to the understanding of most complex systems.
Defining a baseline state in the human brain, arguably our most complex system, poses a …

Functional neuroimaging studies have started unravelling unexpected functional attributes
for the posteromedial portion of the parietal lobe, the precuneus. This cortical area has …