Human organs-on-chips for disease modelling, drug development and personalized medicine
DE Ingber - Nature Reviews Genetics, 2022 - nature.com
The failure of animal models to predict therapeutic responses in humans is a major problem
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …
Cytokines and intestinal epithelial permeability: A systematic review
F Meyer, D Wendling, C Demougeot, C Prati… - Autoimmunity …, 2023 - Elsevier
Background The intestinal mucosa is composed of a well-organized epithelium, acting as a
physical barrier to harmful luminal contents, while simultaneously ensuring absorption of …
physical barrier to harmful luminal contents, while simultaneously ensuring absorption of …
Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery
N Sunildutt, P Parihar… - Frontiers in …, 2023 - frontiersin.org
The inefficiency of existing animal models to precisely predict human pharmacological
effects is the root reason for drug development failure. Microphysiological system/organ-on …
effects is the root reason for drug development failure. Microphysiological system/organ-on …
Gut-on-a-chip models for dissecting the gut microbiology and physiology
A Valiei, J Aminian-Dehkordi, MRK Mofrad - APL bioengineering, 2023 - pubs.aip.org
Microfluidic technologies have been extensively investigated in recent years for developing
organ-on-a-chip-devices as robust in vitro models aiming to recapitulate organ 3D …
organ-on-a-chip-devices as robust in vitro models aiming to recapitulate organ 3D …
Understanding disruption of the gut barrier during inflammation: Should we abandon traditional epithelial cell lines and switch to intestinal organoids?
S Lechuga, MB Braga-Neto, NG Naydenov… - Frontiers in …, 2023 - frontiersin.org
Disruption of the intestinal epithelial barrier is a hallmark of mucosal inflammation. It
increases exposure of the immune system to luminal microbes, triggering a perpetuating …
increases exposure of the immune system to luminal microbes, triggering a perpetuating …
Gut-on-a-Chip Models: Current and Future Perspectives for Host–Microbial Interactions Research
The intestine contains the largest microbial community in the human body, the gut
microbiome. Increasing evidence suggests that it plays a crucial role in maintaining overall …
microbiome. Increasing evidence suggests that it plays a crucial role in maintaining overall …
Thin and stretchable extracellular matrix (ECM) membrane reinforced by nanofiber scaffolds for developing in vitro barrier models
An extracellular matrix (ECM) membrane made up of ECM hydrogels has great potentials to
develop a physiologically relevant organ-on-a-chip because of its biochemical and …
develop a physiologically relevant organ-on-a-chip because of its biochemical and …
Integrated technologies for continuous monitoring of organs-on-chips: Current challenges and potential solutions
Abstract Organs-on-chips (OoCs) are biomimetic in vitro systems based on microfluidic cell
cultures that recapitulate the in vivo physicochemical microenvironments and the …
cultures that recapitulate the in vivo physicochemical microenvironments and the …
[HTML][HTML] Human organoids-on-chips for biomedical research and applications
Human organoids-on-chips (OrgOCs) are the synergism of human organoids (HOs)
technology and microfluidic organs-on-chips (OOCs). OOCs can mimic extrinsic …
technology and microfluidic organs-on-chips (OOCs). OOCs can mimic extrinsic …
Integrating liver-chip data into pharmaceutical decision-making processes
D Levner, L Ewart - Expert Opinion on Drug Discovery, 2023 - Taylor & Francis
Introduction Drug-induced liver injury (DILI) is a potentially lethal condition that heavily
impacts the pharmaceutical industry, causing approximately 21% of drug withdrawals and …
impacts the pharmaceutical industry, causing approximately 21% of drug withdrawals and …