Addictions are highly heritable disorders, with heritability estimates ranging from 39% to
72%. Multiple studies suggest a link between paternal drug abuse and addiction in their …

Individual differences are a hallmark of drug addiction. Here, we describe a rat model based
on differential initial responsiveness to low dose cocaine. Despite similar brain cocaine …

The dopamine transporter (DAT) is the primary site of action for psychostimulant drugs such
as cocaine, methylphenidate, and amphetamine. Our previous work demonstrated a …

Impulsivity and hyperactivity are two facets of attention deficit/hyperactivity disorder (ADHD).
Impulsivity is expressed as reduced response inhibition capacity, an executive control …

Dopamine (DA) homeostasis is essential for a variety of brain activities. Dopamine
transporter (DAT)-mediated DA reuptake is one of the most critical mechanisms for normal …

Cocaine (benzoylmethylecgonine), a natural alkaloid, is a powerful psychostimulant and a
highly addictive drug. Unfortunately, the relationships between its behavioral and …

Cocaine is a powerful psychostimulant that is one of the most widely used illicit addictive.
The dopamine transporter (DAT) plays a major role in mediating cocaine's reward effect …

Attention deficit/hyperactivity disorder (ADHD) is attributed to dysfunction of the prefrontal
cortex. Methylphenidate, an inhibitor of dopamine and norepinephrine transporters (DAT …

J. Neurochem.(2011) 117, 133–142. Abstract The dopaminergic terminal field in the rat
striatum is compartmentalized into sub‐domains that exhibit distinct dynamics of electrically …

Variations in the expression levels of the dopamine transporter (DAT) can influence
responsiveness to psychostimulant drugs like cocaine. To better understand this …