Intercalating nucleic acids containing insertions of 1‐ O ‐(1‐pyrenylmethyl)glycerol: stabilisation of dsDNA and discrimination of DNA over RNA
UB Christensen, EB Pedersen - Nucleic Acids Research, 2002 - academic.oup.com
We have studied hybridisation affinities and fluorescence behaviour of intercalator‐modified
oligonucleotides. The phosphoramidite of (S)‐1‐O‐(4, 4′‐dimethoxytriphenylmethyl)‐3‐O …
oligonucleotides. The phosphoramidite of (S)‐1‐O‐(4, 4′‐dimethoxytriphenylmethyl)‐3‐O …
Novel phosphoramidite building blocks in synthesis and applications toward modified oligonucleotides
N Venkatesan, SJ Kim, BH Kim - Current medicinal chemistry, 2003 - ingentaconnect.com
In recent years modified oligonucleotides (oligos) have become an area of increased
research activity. These synthetic biopolymers have long been used as molecular probes to …
research activity. These synthetic biopolymers have long been used as molecular probes to …
Oligonucleotides with alternating segments of locked and non-locked nucleotides
CA Thrue, C Rosenbohm, HF Hansen… - US Patent …, 2010 - Google Patents
The present invention is directed to novel oligonucleotides with improved antisense
properties. The novel oligonucle otides comprise at least one Locked Nucleic Acid (LNA) …
properties. The novel oligonucle otides comprise at least one Locked Nucleic Acid (LNA) …
Oligonucleotides and oligonucleotide conjugates: a new approach for cancer treatment
In this account we summarise recent studies on oligonucleotides and oligonucleotide
derivatives and their utilisation in antigene, antisense and decoy approaches, with particular …
derivatives and their utilisation in antigene, antisense and decoy approaches, with particular …
Amino-LNA, thio-LNA and alpha-L-oxy-LN
SM Christensen, ND Mikkelsen, M Frieden… - US Patent …, 2015 - Google Patents
(. 01) Wahlestedt et al.,“Potent and nontoxic antisense oligonucleotides C7H 2L/00(2006.01)
containing locked nucleic acids”, PNAS, 97 (10): 5633-5638 (2000). CI2N IS/II(2006.01) …
containing locked nucleic acids”, PNAS, 97 (10): 5633-5638 (2000). CI2N IS/II(2006.01) …
Exploring the role of chirality in nucleic acid recognition
The study of the base‐pairing properties of nucleic acids with sugar moieties in the
backbone belonging to the l‐series (β‐l‐DNA, β‐l‐RNA, and their analogs) are reviewed …
backbone belonging to the l‐series (β‐l‐DNA, β‐l‐RNA, and their analogs) are reviewed …
Antisense design
SM Christensen, ND Mikkelsen, M Frieden… - US Patent …, 2016 - Google Patents
(57) ABSTRACT A novel class of pharmaceuticals which comprises a Locked Nucleic Acid
(LNA) which can be used in antisense therapy. These novel oligonucleotides have improved …
(LNA) which can be used in antisense therapy. These novel oligonucleotides have improved …
Structure-editing of nucleic acids for selective targeting of RNA
VA Kumar, KN Ganesh - Current Topics in Medicinal Chemistry, 2007 - ingentaconnect.com
The synthesis of backbone-modified nucleic acids has been an area of very intense
research over the last two decades. The main reason for this research activity is the …
research over the last two decades. The main reason for this research activity is the …
Methods and compositions for detecting polynucleotides
IICR Bupp, KY Choi, RA Holmes-Davis… - US Patent …, 2011 - Google Patents
2007-06-06 Assigned to INVESTIGEN, INC. reassignment INVESTIGEN, INC. ASSIGNMENT
OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: URDEA …
OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: URDEA …
Antisense design
SM Christensen, ND Mikkelsen, M Frieden… - US Patent …, 2017 - Google Patents
EP O618925 10, 1994 EP 1152009 11 2001 EP 1222309 T 2002 EP 1251.183 10, 2002 WO
WO98/39352 9/1998 WO WO99, 14226 3, 1999 WO OO, 56748 9, 2000 WO WOOOf 66604 …
WO98/39352 9/1998 WO WO99, 14226 3, 1999 WO OO, 56748 9, 2000 WO WOOOf 66604 …