Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their
poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a …

Enhanced joint synergistic lubrication combined with anti-inflammatory therapy is an
effective strategy to delay the progression of early osteoarthritis (OA) but has been rarely …

Cancer is still the leading disease threatening human life and health at present. With the
development of nanotechnology, multifunctional nanomaterials integrated with different …

With the change in lifestyle and aging of the population, osteoarthritis (OA) is emerging as a
major medical burden globally. OA is a chronic inflammatory and degenerative disease …

Tissue regeneration is an active multiplex process involving the dynamic inflammatory
microenvironment. Under a normal physiological framework, inflammation is necessary for …

Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) show great
therapeutic potential for osteoarthritis (OA). However, their low bioavailability through …

The occurrence of osteoarthritis (OA) is highly associated with the inflammatory hypoxic
microenvironment. Yet currently no attention has been paid to fabricating hypoxia …

Targeting cartilage is a promising strategy for the treatment of osteoarthritis, and various
delivery vehicles were developed to assist the therapeutic agents into cartilage. However …

Oxidative stress and inflammation are two related processes common to many diseases.
Curcumin is a natural compound with both antioxidant and anti-inflammatory properties …

Reactive oxygen species (ROS) play distinct but important roles in physiological and
pathophysiological processes. Recent studies on osteoarthritis (OA) have suggested that …