Surface-attached layers of phosphatidylcholine (PC) lipid vesicles (liposomes) may reduce
the friction coefficient μ (= force-to-slide/load) between the sliding surfaces down to μ≈ 10 …

Inflammation that is not resolved in due course becomes a chronic disease. The treatment of
chronic inflammatory diseases involves a long-term use of anti-inflammatory drugs such as …

Herein, inspired by the structure of phosphatidylcholine lipid (a typical cartilage matrix) with
the presence of zwitterionic charges, a bottlebrush polymer was developed, namely poly (4 …

Osteoarthritis (OA) is a degenerative joint disease and is the main cause of chronic pain and
functional disability in adults. Articular cartilage is a hydrated soft tissue that is composed of …

One important challenge in treating avascular-degraded cartilage is the development of new
drugs for both pain management and joint preservation. Considerable efforts have been …

Nanomaterials have been extensively used in several applications in the past few decades
related to biomedicine and healthcare. Among them, nanogels (NGs) have emerged as an …

Osteoarthritis (OA) is considered to be the most common joint disorder. Exogenous drug
intervention is one of the effective means for OA treatment. Clinical applications of numerous …

Osteoarthritis (OA) is a prevalent global health concern, posing a significant and increasing
public health challenge worldwide. Recently, nanotechnology-boosted biomaterials have …

Excessive mechanical strain is the prominent risk factor for osteoarthritis (OA), causing
cartilage destruction and degeneration. However, the underlying molecular mechanism …

Charge-based drug delivery has proven to be effective for targeting negatively charged
cartilage for the treatment of osteoarthritis. Cartilage is surrounded by synovial fluid (SF) …