The remarkable lubrication properties of normal articular cartilage play an essential role in
daily life, providing almost frictionless movements of joints. Alterations of cartilage surface or …

While the early detection and repair of cartilage lesions are crucial in the treatment of
osteoarthritis (OA), they remain challenging because neither clinically used medicines nor …

Objective Kartogenin (KGN) has proven as a both chondrogenic and chondroprotective drug
for osteoarthritis (OA) therapy. However, being a small hydrophobic molecule, KGN suffers …

Background Hyaluronic acid (HA) is a popular biological material for osteoarthritis (OA)
treatment. Pioglitazone, a PPAR-γ agonist, has been found to inhibit OA, but its use is limited …

Inflammation following joint trauma contributes to cartilage degradation and progression of
post traumatic osteoarthritis (PTOA). Therefore, drug delivery vehicles that deliver effective …

The purpose of cartilage tissue engineering is to provide artificial constructs with biological
functions and mechanical features that resemble native tissue to improve tissue …

Oxidative stress is an important, but elusive, therapeutic target for osteoarthritis (OA).
Antioxidant strategies that target oxidative stress through the elimination of reactive oxygen …

Nanoparticles are under investigation as diagnostic and therapeutic agents for joint
diseases, such as osteoarthritis. However, there is incomplete understanding of nanoparticle …

Osteoarthritis (OA) represents an enduring and widespread global burden, causing
significant morbidity and disability, whose pathology is characterized by persistent …

Purpose Pain and cartilage destruction caused by rheumatoid arthritis (RA) are major
challenges during clinical treatment. Traditional systemic administration not only has …