Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment
Novel intra-articular nanoreservoirs were implemented employing different cartilage
targeting approaches to improve cartilage bioavailability of a chondroprotective drug, cassic …
targeting approaches to improve cartilage bioavailability of a chondroprotective drug, cassic …
[HTML][HTML] Harnessing the multifunctionality of lipid-based drug delivery systems for the local treatment of osteoarthritis
Osteoarthritis (OA) is a widespread joint condition affecting millions globally, presenting a
growing socioeconomic burden thus making the development of more effective therapeutic …
growing socioeconomic burden thus making the development of more effective therapeutic …
Designing polymers for cartilage uptake: effects of architecture and molar mass
Osteoarthritis (OA) is a progressive disease, involving the progressive breakdown of
cartilage, as well as changes to the synovium and bone. There are currently no disease …
cartilage, as well as changes to the synovium and bone. There are currently no disease …
[HTML][HTML] Candidates for intra-articular administration therapeutics and therapies of osteoarthritis
E Toyoda, M Maehara, M Watanabe… - International journal of …, 2021 - mdpi.com
Osteoarthritis (OA) of the knee is a disease that significantly decreases the quality of life due
to joint deformation and pain caused by degeneration of articular cartilage. Since the …
to joint deformation and pain caused by degeneration of articular cartilage. Since the …
The clearance and biodistribution of magnetic composite nanoparticles in healthy and osteoarthritic rat knees
Intra-articular injections are the most direct route for administering osteoarthritis (OA)
therapies, yet how drug carriers distribute within the joint remains understudied. To this end …
therapies, yet how drug carriers distribute within the joint remains understudied. To this end …
Intra-articular injection of biologic anti-rheumatic drugs enhances local exposure to the joint-draining lymphatics
AD Lam, E Cao, N Leong, G Gracia, CJH Porter… - European Journal of …, 2022 - Elsevier
Recent reports have highlighted the role of the lymphatic system and its resident immune
cells in the development of inflammatory arthritis. Directing therapeutics to the joint-draining …
cells in the development of inflammatory arthritis. Directing therapeutics to the joint-draining …
Nanotechnology and Osteoarthritis. Part 2: Opportunities for advanced devices and therapeutics
Osteoarthritis (OA) is a multifactorial disease of the entire joint which afflicts 140 million
individuals worldwide regardless of economic or social status. Current clinical treatments for …
individuals worldwide regardless of economic or social status. Current clinical treatments for …
Unravelling micro and nano vesicular system in intranasal drug delivery for epilepsy
Background: Epilepsy is one of the major neurological disorders, affecting about 50 million
people globally. Oral, intravenous and rectal delivery systems are available for the …
people globally. Oral, intravenous and rectal delivery systems are available for the …
Nanoparticle‐Based Drug Delivery System—A Target Strategy for Osteoarthritis Treatment
K Liu, D Zhang, W Wang - Journal of Nanomaterials, 2021 - Wiley Online Library
Osteoarthritis (OA) is a bone and joint disease with pathological characteristics such as
articular cartilage degeneration injury and synovial and subchondral bone reactive …
articular cartilage degeneration injury and synovial and subchondral bone reactive …
[HTML][HTML] Dual delivery of TGF-β3 and ghrelin in microsphere/hydrogel systems for cartilage regeneration
Articular cartilage (AC) damage is quite common, but due to AC's poor self-healing ability,
the damage can easily develop into osteoarthritis (OA). To solve this problem, we developed …
the damage can easily develop into osteoarthritis (OA). To solve this problem, we developed …