An atypically large outbreak of Elizabethkingia anophelis infections occurred in Wisconsin.
Here we show that it was caused by a single strain with thirteen characteristic genomic …

Bacteriophages are large and diverse components of the biosphere, and many phages are
temperate. Upon infection, temperate phages can establish lysogeny in which a prophage is …

Bacteroides spp. are one of the more prevalent members of the human colonic microbiota,
representing approximately 40% of the bacterial community (1). Bacteroides spp. are …

Conjugative transposition drives the emergence of multidrug resistance in diverse bacterial
pathogens, yet the mechanisms are poorly characterized. The Tn1549 conjugative …

This article reviews the history of widespread exchanges of genetic segments initiated over
3 billion years ago, to be part of their life style, by sphero-protoplastic cells, the ancestors of …

IntDOT is a tyrosine recombinase encoded by the conjugative transposon CTnDOT. The
core binding (CB) and catalytic (CAT) domains of IntDOT interact with core-type sites …

Excision of the conjugative transposon CTnDOT from the chromosome of Bacteroides spp.
involves four CTnDOT-encoded proteins: IntDOT, Xis2c, Xis2d, and Exc along with a host …

CTnDOT is a conjugative transposon found in Bacteroides species. It encodes multiple
antibiotic resistances and is stimulated to transfer by exposure to tetracycline. CTnDOT …

Excision from the chromosome is the first step during the transfer of conjugative transposons
(CTns) to a recipient. We previously showed that the excision of CTnDOT is more complex …

Temperate coliphage P2 integrates its genome into the host chromosome upon
lysogenization via a site-specific recombination event mediated by an integrase belonging …