Mechanistic pathways of sex differences in cardiovascular disease

V Regitz-Zagrosek, G Kararigas - Physiological reviews, 2016 - journals.physiology.org
Major differences between men and women exist in epidemiology, manifestation,
pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as …

Estrogen synthesis and signaling pathways during aging: from periphery to brain

J Cui, Y Shen, R Li - Trends in molecular medicine, 2013 - cell.com
Estrogens are the primary female sex hormones and play important roles in both
reproductive and non-reproductive systems. Estrogens can be synthesized in non …

The importance of biological sex and estrogen in rodent models of cardiovascular health and disease

CL Blenck, PA Harvey, JF Reckelhoff… - Circulation …, 2016 - Am Heart Assoc
Nearly one-third of deaths in the United States are caused by cardiovascular disease (CVD)
each year. In the past, CVD was thought to mainly affect men, leading to the exclusion of …

Estrogen, hormonal replacement therapy and cardiovascular disease

XP Yang, JF Reckelhoff - Current opinion in nephrology and …, 2011 - journals.lww.com
Estrogen, hormonal replacement therapy and cardiovascular di... : Current Opinion in
Nephrology and Hypertension Estrogen, hormonal replacement therapy and cardiovascular …

Sex-specific influence on cardiac structural remodeling and therapy in cardiovascular disease

EL Kessler, MR Rivaud, MA Vos… - Biology of sex …, 2019 - Springer
Abstract Background Cardiovascular diseases (CVDs) culminating into heart failure (HF) are
major causes of death in men and women. Prevalence and manifestation, however, differ …

Gender differences in cardiac hypertrophy

J Wu, F Dai, C Li, Y Zou - Journal of Cardiovascular Translational …, 2020 - Springer
Cardiac hypertrophy is an adaptive response to abnormal physiological and pathological
stimuli, which can be classified into concentric and eccentric hypertrophy, induced by …

Sex differences in in-hospital mortality in acute decompensated heart failure with reduced and preserved ejection fraction

EM Hsich, MV Grau-Sepulveda, AF Hernandez… - American heart …, 2012 - Elsevier
BACKGROUND: There are no sex-specific survival comparisons between patients with heart
failure (HF) with reduced and those with preserved ejection fraction. Large registries noting …

Role of various proteases in cardiac remodeling and progression of heart failure

AL Müller, NS Dhalla - Heart failure reviews, 2012 - Springer
It is believed that cardiac remodeling due to geometric and structural changes is a major
mechanism for the progression of heart failure in different pathologies including …

Apoptosis and autophagy contribute to gender difference in cardiac ischemia–reperfusion induced injury in rats

C Chen, LX Hu, T Dong, GQ Wang, LH Wang, XP Zhou… - Life sciences, 2013 - Elsevier
Aims Gender difference in cardiac ischemia–reperfusion (IR) induced injury has been
reported in animal models. However, a large-scale clinical trial found an increase in …

Sex-dependent mechanisms of cell death modalities in cardiovascular disease

C Horvath, G Kararigas - Canadian Journal of Cardiology, 2022 - Elsevier
Despite currently available therapies, cardiovascular diseases (CVD) are among the leading
causes of death globally. Biological sex is a critical determinant of the occurrence …