[HTML][HTML] PROTEOSTASIS: A European network to break barriers and integrate science on protein homeostasis

N Dissmeyer, O Coux, MS Rodriguez… - Trends in biochemical …, 2019 - cell.com
Protein homeostasis (proteostasis) is at the core of cellular functions. The European network
PROTEOSTASIS was created to steer research and foster collaborations in the …

Cullin-RING ligase regulation by the COP9 signalosome: structural mechanisms and new physiologic players

F Rao, H Lin, Y Su - Cullin-RING Ligases and Protein Neddylation: Biology …, 2020 - Springer
Abstract The Cullin-RING E3 ligases (CRLs) are major ubiquitylation machineries regulated
by reversible cycles of neddylation and deneddylation. The deneddylase COP9 …

IKK-Mediated Regulation of the COP9 Signalosome via Phosphorylation of CSN5

J Zhang, R Zhao, C Yu, CLN Bryant, K Wu… - Journal of proteome …, 2020 - ACS Publications
The COP9 signalosome (CSN) is an evolutionarily conserved multisubunit protein complex,
which controls protein degradation through deneddylation and inactivation of cullin-RING …

[PDF][PDF] Specific ubiquitin-dependent protein degradation requires a trimeric CandA complex in Aspergillus nidulans

AM Köhler - 2019 - core.ac.uk
E3 cullin-RING ubiquitin ligase complexes are activated by modification of their cullin
scaffold protein with the ubiquitin-like modifier Nedd8. Deneddylases as the COP9 …