Bioisosteres of the phenyl ring: recent strategic applications in lead optimization and drug design

MAM Subbaiah, NA Meanwell - Journal of Medicinal Chemistry, 2021 - ACS Publications
The benzene moiety is the most prevalent ring system in marketed drugs, underscoring its
historic popularity in drug design either as a pharmacophore or as a scaffold that projects …

Recent progress in cyclic aryliodonium chemistry: syntheses and applications

X Peng, A Rahim, W Peng, F Jiang, Z Gu… - Chemical …, 2023 - ACS Publications
Hypervalent aryliodoumiums are intensively investigated as arylating agents. They are
excellent surrogates to aryl halides, and moreover they exhibit better reactivity, which allows …

Recent Advances in Visible‐Light‐Driven C− S Bond Formation

J Feng, Y Zhang, X Wang, J Liu… - Advanced Synthesis …, 2023 - Wiley Online Library
Due their multifaced applications, the access to organosulfur derivatives in an efficient and
economical way is a challenge in organic synthesis. In this context photochemistry and …

Applications of isosteres of piperazine in the design of biologically active compounds: part 1

NA Meanwell, O Loiseleur - Journal of Agricultural and Food …, 2022 - ACS Publications
Piperazine and homopiperazine are well-studied heterocycles in drug design that have
found gainful application as scaffolds and terminal elements and for enhancing the aqueous …

Photoinduced C(sp3)–H Chalcogenation of Amide Derivatives and Ethers via Ligand-to-Metal Charge-Transfer

B Niu, K Sachidanandan, MV Cooke, TE Casey… - Organic …, 2022 - ACS Publications
A photoinduced, iron (III) chloride-catalyzed C–H activation of N-methyl amides and ethers
leads to the formation of C–S and C–Se bonds via a ligand-to-metal charge transfer (LMCT) …

Enantio‐, Diastereo‐ and Regioselective Synthesis of Chiral Cyclic and Acyclic gem‐Difluoromethylenes by Palladium‐Catalyzed [4+2] Cycloaddition

H Uno, K Kawai, T Araki, M Shiro… - Angewandte …, 2022 - Wiley Online Library
Abstract gem‐Difluoromethylene moieties are attractive in medicinal chemistry due to their
ability to mimic other more ubiquitous functional groups. Thus, effective asymmetric methods …

Small Molecule Inhibitors Targeting the “Undruggable” Survivin: The Past, Present, and Future from a Medicinal Chemist's Perspective

Q Cui, C Huang, JY Liu, JT Zhang - Journal of Medicinal …, 2023 - ACS Publications
Survivin, a homodimeric protein and a member of the IAP family, plays a vital function in cell
survival and cycle progression by interacting with various proteins and complexes. Its …

Database of 4 Million Medicinal Chemistry-Relevant Ring Systems

P Ertl - Journal of chemical information and modeling, 2024 - ACS Publications
Central ring systems are the most important part of bioactive molecules. They determine
molecule shape, keep substituents in their proper positions, and also influence global …

Diaryl-pyrazinoporphyrins–Prospective photocatalysts for efficient sulfoxidation

DA Polivanovskaia, IA Abdulaeva, KP Birin… - Journal of …, 2022 - Elsevier
New promising photoactive functionalized pyrazinoporphyrins were prepared and
preliminarily tested as homogeneous catalysts in the photooxidation of organic sulfides. An …

Placing CF2 in the Center: Major Physicochemical Changes Upon a Minor Structural Alteration in Gem‐Difunctional Compounds

S Saphier, S Katalan, G Yacov… - … A European Journal, 2023 - Wiley Online Library
Fluorine atoms play an important role in all branches of chemistry and accordingly, it is very
important to study their unique and varied effects systematically, in particular, the structure …