Vitamin C (L-ascorbic acid) has been known as an antioxidant for most people. However, its
physiological role is much larger and encompasses very different processes ranging from …

Vitamin C is an essential micronutrient for humans, with pleiotropic functions related to its
ability to donate electrons. It is a potent antioxidant and a cofactor for a family of biosynthetic …

Normal cells produce adenosine 5′-triphosphate (ATP) mainly through mitochondrial
oxidative phosphorylation (OXPHOS) when oxygen is available. Most cancer cells, on the …

Nutrition plays an essential role in the regulation of optimal immunological response, by
providing adequate nutrients in sufficient concentrations to immune cells. There are a large …

Cancer is a disease at the cellular level involving heritable disorders in cellular control
mechanism. Cancer cells also need to adapt their metabolism to survive and multiply under …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator of various genes related to
cellular adaptive responses to hypoxia. Dysfunctions in the regulatory systems of HIF‐1 …

SIRT6 is a member of a highly conserved family of NAD+-dependent deacetylases with
various roles in metabolism, stress resistance, and life span. SIRT6-deficient mice develop …

Over the last decade, extraordinary progress has been made in elucidating the underlying
genetic causes of gliomas. In 2008, our understanding of glioma genetics was …

Currently, radiation therapy is one of the standard therapies for cancer treatment. Since the
first applications, the field of radiotherapy has constantly improved, both in imaging …