Cell-based therapy is a promising strategy for treating chronic kidney disease (CKD) and is
currently the focus of preclinical studies. We performed a systematic review and meta …

This manuscript comprehensively reviews the interrelationship between spermatogonial
stem cells (SSCs) and the JAK/STAT signaling pathway. Spermatogonial stem cells in the …

Acute kidney injury (AKI) is frequent, often fatal and, for lack of specific therapies, can leave
survivors with chronic kidney disease (CKD). We characterize the distribution of tubular cells …

Acute kidney injury (AKI) is defined as a rapid loss of renal function resulting from various
etiologies, with a mortality rate exceeding 60% among intensive care patients. Because …

Ischemia-reperfusion injury (IRI) plays a significant role in the pathogenesis of acute kidney
injury (AKI). The complicated interaction between injured tubular cells, activated endothelial …

Acute kidney injury is a frequent complication of hospitalized patients and significantly
increases morbidity and mortality, worsening costs and length of hospital stay. Despite this …

Tissue fibrosis is characterized by excessive deposition of extracellular matrix (ECM)
components that result from the disruption of regulatory processes responsible for ECM …

The ability of the human kidney to repair itself is limited. Consequently, repeated injury can
trigger a maladaptive response that is characterized by fibrosis and loss of renal function …

Background The therapeutic effect of mesenchymal stem cells (MSCs) from human adipose
tissue on renal interstitial fibrosis has been demonstrated by several groups. However, the …

Cell therapy using renal progenitors differentiated from human embryonic stem cells
(hESCs) or induced pluripotent stem cells (hiPSCs) has the potential to significantly reduce …