The Comet Assay as a Tool in Human Biomonitoring Studies of Environmental and Occupational Exposure to Chemicals—A Systematic Scoping Review

C Ladeira, P Møller, L Giovannelli, G Gajski, A Haveric… - Toxics, 2024 - mdpi.com
Biomonitoring of human populations exposed to chemical substances that can act as
potential mutagens or carcinogens, may enable the detection of damage and early disease …

Altered Transcriptome Response in PBMCs of Czech Adults Linked to Multiple PFAS Exposure: B Cell Development as a Target of PFAS Immunotoxicity

B Rudzanová, V Thon, H Vespalcová… - Environmental …, 2023 - ACS Publications
While the immunomodulation effects of per-and polyfluoroalkyl substances (PFASs) are
described on the level of clinical signs in epidemiological studies (eg, suppressed antibody …

Association between polycyclic aromatic hydrocarbon exposure and liver function: the mediating roles of inflammation and oxidative stress

S Zhou, C Guo, Y Dai, X Pan, X Luo, P Qin, L Tan - Environmental Pollution, 2024 - Elsevier
Polycyclic aromatic hydrocarbon (PAH) exposure has been associated with adverse health
effects, and accumulating evidence suggests that PAH exposure may impair liver function …

[HTML][HTML] The use of effect biomarkers in chemical mixtures risk assessment–Are they still important?

C Ladeira - Mutation Research-Genetic Toxicology and …, 2024 - Elsevier
Human epidemiological studies with biomarkers of effect play an invaluable role in
identifying health effects with chemical exposures and in disease prevention. Effect …

Exploring cytokinesis block micronucleus assay in Croatia: A journey through the past, present, and future in biomonitoring of the general population

G Gajski, V Kašuba, M Milić, M Gerić, K Matković… - … -Genetic Toxicology and …, 2024 - Elsevier
In this study, we used the cytokinesis-block micronucleus (CBMN) assay to evaluate the
background frequency of cytogenetic damage in peripheral blood lymphocytes of the …

A revised concept for deriving reference values for internal exposures to chemical substances and its application to population-representative biomonitoring data in …

M Hoopmann, A Murawski, M Schümann… - International Journal of …, 2023 - Elsevier
HBM reference values, in contrast to toxicologically derived values, are statistically derived
values that provide information on the exposure of the population. The exceedance …

Urinary phthalate/DINCH metabolites associations with kisspeptin and reproductive hormones in teenagers: A cross-sectional study from the HBM4EU aligned studies

A Rodríguez-Carrillo, S Remy, G Koppen… - Science of The Total …, 2024 - Elsevier
Background Exposure to phthalate/DINCH metabolites can induce human reproductive
toxicity, however, their endocrine-disrupting mechanisms are not fully elucidated. Objective …

Brain-derived neurotrophic factor (BDNF): an effect biomarker of neurodevelopment in human biomonitoring programs

A Rodríguez-Carrillo, VJ Verheyen… - Frontiers in …, 2024 - frontiersin.org
The present narrative review summarizes recent findings focusing on the role of brain-
derived neurotrophic factor (BDNF) as a biomarker of effect for neurodevelopmental …

[PDF][PDF] and Environmental Mutagenesis

C Ladeira, R Araújo, L Ramalhete… - Mutation Research …, 2024 - research.unl.pt
Human epidemiological studies with biomarkers of effect play an invaluable role in
identifying health effects with chemical exposures and in disease prevention. Effect …

[PDF][PDF] Key results of the european human biomonitoring initiative-HBM4EU

M Kolossa-Gehring, G Schoeters… - … journal of hygiene …, 2023 - repository.uantwerpen.be
Human Biomonitoring (HBM) has increasingly become an established tool for the risk
assessment of chemicals, chemical's safety, and for the steering of chemical policies in …