Folic acid plays a key role in the maintenance of genomic stability, providing methyl groups
for the conversion of uracil to thymine and for DNA methylation. Besides dietary habits, folic …

The association between methylenetetrahydrofolate reductase (MTHFR) gene
polymorphisms and breast cancer risk has been widely reported, but results were …

Background Folate is involved in DNA synthesis and methylation and may thereby influence
carcinogenesis. Objectives We examined plasma folate (P-folate) concentration in relation to …

In view of growing body of evidence substantiating the role of aberrations in one-carbon
metabolism in the pathophysiology of breast cancer and lack of studies on gene–gene …

Breast cancer is the second leading cause of cancer mortality among women. Given its
important role in DNA methylation and synthesis, one-carbon metabolism may affect breast …

To evaluate the relationship between dietary folate intake and genetic polymorphisms of 5,
10-methylenetetrahydrofolate reductase (MTHFR) with reference to breast cancer risk, we …

Single-nucleotide polymorphisms (SNPs) within genes of the one-carbon metabolism
pathway have been shown to interact with dietary folate intake to modify breast cancer (BC) …

We have earlier demonstrated the role of aberrant one‐carbon metabolism in the etiology of
breast cancer. In the current study, we examine the clinical utility of these factors in …

One-carbon metabolism facilitates the crosstalk between genetic and epigenetic processes
and plays critical roles in both DNA methylation and DNA synthesis, making it a good …

Background The association between MHTFR Ala222Val polymorphism and breast cancer
(BC) risk are inconclusive. To derive a more precise estimation of the relationship, a …