(Q) SARs to predict environmental toxicities: current status and future needs

MTD Cronin - Environmental Science: Processes & Impacts, 2017 - pubs.rsc.org
The current state of the art of (Quantitative) Structure–Activity Relationships ((Q) SARs) to
predict environmental toxicity is assessed along with recommendations to develop these …

New models for the time dependent toxicity of individual and combined toxicants

RJW Lambert, DA Dawson - Toxicology Research, 2019 - academic.oup.com
Time-dependent toxicity data of specific toxicants observed against A. fischeri were
analysed using a single time-dependent Weibull cumulative distribution function (CDF). For …

[PDF][PDF] Isobolographic analysis of interactions–a pre-clinical perspective

JJ Łuszczki, A Wlaź - Journal of Pre-Clinical and Clinical Research, 2023 - jpccr.eu
Introduction. Isobolographic analysis is the preferred method of assessment of
pharmacodynamic interactions occurring among drugs administered in mixture in both pre …

[HTML][HTML] Evaluation of time-dependent toxicity and combined effects for a series of mono-halogenated acetonitrile-containing binary mixtures

DA Dawson, D Guinn, G Pöch - Toxicology reports, 2016 - Elsevier
Mixture and time-dependent toxicity (TDT) was assessed for a series of mono-halogenated
acetonitrile-containing combinations. Inhibition of bioluminescence in Aliivibrio fischeri was …

Implications of a statistical occurrence model for mixture toxicity estimation

NH Orak, MJ Small - Human and Ecological Risk Assessment: An …, 2017 - Taylor & Francis
This study provides a method for characterizing the effects of concentration variability and
correlation among co-acting compounds on mixture toxicity, considering the implications of …

A toxicological application of signal transduction: early cellular changes can be indicative of toxicity

JV Miller, N Prince, JA Mouch… - … Signal Transduction in …, 2019 - Wiley Online Library
This chapter discusses the experimental conditions and assays capable of capturing
relevant mechanistic information for toxicity testing. A better understanding of the …

Evaluation of consistency for multiple experiments of a single combination in the time-dependence mixture toxicity assay

DA Dawson, G Pöch - Toxicology mechanisms and methods, 2017 - Taylor & Francis
Test-to-test consistency was evaluated for a single binary combination of organic chemicals
using an assay that examined toxicity over multiple exposure times. Six experiments were …

Iodoacetonitrile

GL Bundy, C Nájera, JM Sansano… - … of Reagents for Organic …, 2001 - Wiley Online Library
Abstract InChI= 1S/C2H2IN/c3‐1‐2‐4/h1H2 InChIKey= VODKOOOHHCAWFR‐
UHFFFAOYSA‐N (used for alkylation of nucleophiles; undergoes Reformatsky and Wittig …