Effective screening for major aneuploidies can be provided in the first trimester of
pregnancy. Screening by a combination of fetal nuchal translucency and maternal serum …

The sequencing of chromosome 21 and the use of models of Down's syndrome in mice have
allowed us to relate genes and sets of genes to the neuropathogenesis of this syndrome …

An exposé on Big Pharma and the American healthcare system's zeal for excessive medical
testing, from a nationally recognized expert More screening doesn't lead to better health …

More and more systematic reviews of diagnostic test accuracy studies are being published,
but they can be methodologically challenging. In this paper, the authors present some of the …

Objective To summarize by meta‐analysis the accumulated data on the screening
performance of second‐trimester sonographic markers for fetal trisomy 21. Methods We …

Background: Studies with methodologic shortcomings can overestimate the accuracy of a
medical test. We sought to determine and compare the direction and magnitude of the …

This paper reviews publications from January 1999 to March 2001 on reproductive health
topics that were self‐identified as meta‐analysis or were indexed as meta‐analysis in …

Objectives To evaluate the evidence for the effectiveness and cost-effectiveness of the
newer diagnostic imaging tests as an addition to clinical examination and patient history for …

To determine whether sonographic" markers" are associated with fetal Down syndrome
during the second trimester and to estimate the degree of risk of individual markers using …

Background: Systematic reviews that “compare” the accuracy of 2 or more tests often include
different sets of studies for each test. Purpose: To investigate the availability of direct …