Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2

YL Kang, Y Chou, PW Rothlauf, Z Liu… - Proceedings of the …, 2020 - National Acad Sciences
Virus entry is a multistep process. It initiates when the virus attaches to the host cell and
ends when the viral contents reach the cytosol. Genetically unrelated viruses can subvert …

TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections

LW Shen, HJ Mao, YL Wu, Y Tanaka, W Zhang - Biochimie, 2017 - Elsevier
Influenza virus and coronavirus epidemics or pandemics have occurred in succession
worldwide throughout the early 21st century. These epidemics or pandemics pose a major …

Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

H Chu, B Hu, X Huang, Y Chai, D Zhou, Y Wang… - Nature …, 2021 - nature.com
Understanding the factors that contribute to efficient SARS-CoV-2 infection of human cells
may provide insights on SARS-CoV-2 transmissibility and pathogenesis, and reveal targets …

Systematic review of the efficacy and safety of antiretroviral drugs against SARS, MERS or COVID‐19: initial assessment

N Ford, M Vitoria, A Rangaraj, SL Norris… - Journal of the …, 2020 - Wiley Online Library
Introduction Several antiretroviral drugs are being considered for the treatment of COVID‐
19, the disease caused by a newly identified coronavirus,(SARS‐CoV‐2). We systematically …

Endocytosis of abiotic nanomaterials and nanobiovectors: Inhibition of membrane trafficking

P Makvandi, M Chen, R Sartorius, A Zarrabi… - Nano Today, 2021 - Elsevier
Humans are exposed to nanoscopical nanobiovectors (eg coronavirus SARS-CoV-2) as
well as abiotic metal/carbon-based nanomaterials that enter cells serendipitously or …

[HTML][HTML] Covid-19 pandemic and food: Present knowledge, risks, consumers fears and safety

A Duda-Chodak, M Lukasiewicz, G Zięć… - Trends in Food Science …, 2020 - Elsevier
Background COVID-19 is a pandemic disease that has paralyzed social life and the
economy around the world since the end of 2019, and which has so far killed nearly 300,000 …

Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells

V Kumar, JK Dhanjal, P Bhargava, A Kaul… - Journal of …, 2022 - Taylor & Francis
Abstract Coronavirus disease 2019 (COVID-19) initiated in December 2019 in Wuhan,
China and became pandemic causing high fatality and disrupted normal life calling world …

D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity

J Hu, CL He, QZ Gao, GJ Zhang, XX Cao, QX Long… - BioRxiv, 2020 - biorxiv.org
Abstract Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein that mediates SARS-CoV-2 …

SARS-CoV-2 and ACE2: The biology and clinical data settling the ARB and ACEI controversy

MK Chung, S Karnik, J Saef, C Bergmann, J Barnard… - …, 2020 - thelancet.com
Background SARS-CoV-2 enters cells by binding of its spike protein to angiotensin-
converting enzyme 2 (ACE2). Angiotensin-converting enzyme inhibitors (ACEIs) or …

Broad-spectrum coronavirus antiviral drug discovery

AL Totura, S Bavari - Expert opinion on drug discovery, 2019 - Taylor & Francis
Introduction: The highly pathogenic coronaviruses severe acute respiratory syndrome
coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) …