In vivo cell fate reprogramming for spinal cord repair

W Tai, CL Zhang - Current opinion in genetics & development, 2023 - Elsevier
Spinal cord injury (SCI) can lead to the loss of motor, sensory, or autonomic function due to
neuronal death. Unfortunately, the adult mammalian spinal cord has limited intrinsic …

Polysaccharides as a promising platform for the treatment of spinal cord injury: A review

Y Yang, R Fan, H Li, H Chen, H Gong, G Guo - Carbohydrate Polymers, 2023 - Elsevier
Spinal cord injury is incurable and often results in irreversible damage to motor function and
autonomic sensory abilities. To enhance the effectiveness of therapeutic substances such as …

[HTML][HTML] Iridium metal complex targeting oxidation resistance 1 protein attenuates spinal cord injury by inhibiting oxidative stress-associated reactive oxygen species

C Peng, J Luo, K Wang, J Li, Y Ma, J Li, H Yang… - Redox Biology, 2023 - Elsevier
Oxidative stress is a key factor leading to profound neurological deficits following spinal cord
injury (SCI). In this study, we present the development and potential application of an iridium …

Restoration of Motor and Bladder Functions after Spinal Cord Injury via Sustained Wogonin Release from Carbon Nanotube Incorporated Hydrogels

Q Zhang, L Zhang, W Weng, X Qiu, Y Zhuang… - ACS Materials …, 2024 - ACS Publications
Spinal cord injury (SCI) results in structural and neural cell damage, leading to motor and
bladder dysfunction. The limited regenerative capabilities and SCI-mediated inflammation …

Succinic acid modified chitosan hydrogel mediates in-situ bioenergetic remodeling of neural cells for neuronal differentiation and spinal cord injury repair

T Xu, J Zhao, M Zhou, B Zhou, F Wu, J He - Chemical Engineering Journal, 2024 - Elsevier
A primary challenge in spinal cord injury repair is the presence of an energy deficit,
exacerbated by the injury itself, thereby intensifying the dilemma of insufficient energy …

[HTML][HTML] Engineering neuroregenerative microenvironment via aligned hydrogel-assisted magnetic stimulation for complete spinal cord injury repair

CY Yang, Z Meng, Z He, P Ma, Z Hou, K Kim, J Lu… - Engineered …, 2024 - Elsevier
Utilizing biomaterials in tissue engineering has shown considerable promise for tissue
regeneration, particularly through delivering multimodel cell-regulatory signals, including the …

Sustained delivery of NT-3 and curcumin augments microenvironment modulation effects of decellularized spinal cord matrix hydrogel for spinal cord injury repair

J Chen, X Cheng, Z Yu, R Deng, R Cui… - Regenerative …, 2024 - academic.oup.com
Decellularized extracellular matrix hydrogel, especially that derived from spinal cord (DSCM
hydrogel), has been actively considered as a functional biomaterial for remodeling the …

[HTML][HTML] A core scientific problem in the treatment of central nervous system diseases: newborn neurons

P Hao, Z Yang, KF So, X Li - Neural Regeneration Research, 2024 - journals.lww.com
It has long been asserted that failure to recover from central nervous system diseases is due
to the system's intricate structure and the regenerative incapacity of adult neurons. Yet over …

Hydrogel encapsulated stem cells facilitate successful repair after spinal cord injury in rats and monkeys

T Li, P Li, H Yuan, X Zhu, L Xiong, S Zhao, J Li, T Chen… - 2023 - researchsquare.com
Promoting axonal regeneration to form nascent circuits after spinal cord injury (SCI) is a
considerable challenge. While cell-based transplantation is considered a top candidate for …

Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitis

Z Lin, W Wang, D Liu, Z Xu, Z Wu, X Zhou, X Zhang… - bioRxiv, 2024 - biorxiv.org
Interstitial cystitis (IC) is a chronic inflammatory disorder characterized by recurring severe
pain in the bladder and surrounding pelvic areas, lacking timely diagnostic and therapeutic …