Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies

PEM de Castilla, L Tong, C Huang, AM Sofias… - Advanced drug delivery …, 2021 - Elsevier
During the past decades, extracellular vesicles (EVs) have emerged as an attractive drug
delivery system. Here, we assess their pre-clinical applications, in the form of a systematic …

Benefits of zebrafish xenograft models in cancer research

X Chen, Y Li, T Yao, R Jia - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
As a promising in vivo tool for cancer research, zebrafish have been widely applied in
various tumor studies. The zebrafish xenograft model is a low-cost, high-throughput tool for …

Green metallic nanoparticles for cancer therapy: evaluation models and cancer applications

E Tinajero-Diaz, D Salado-Leza, C Gonzalez… - Pharmaceutics, 2021 - mdpi.com
Metal-based nanoparticles are widely used to deliver bioactive molecules and drugs to
improve cancer therapy. Several research works have highlighted the synthesis of gold and …

Recent Advancement in Breast Cancer Research: Insights from Model Organisms—Mouse Models to Zebrafish

SS Singhal, R Garg, A Mohanty, P Garg, SK Ramisetty… - Cancers, 2023 - mdpi.com
Simple Summary The current article provides an overview of the significance of using
various mouse and zebrafish models in cancer research. In addition, this review discusses …

Muscle glycogen phosphorylase and its functional partners in health and disease

M Migocka-Patrzałek, M Elias - Cells, 2021 - mdpi.com
Glycogen phosphorylase (PG) is a key enzyme taking part in the first step of glycogenolysis.
Muscle glycogen phosphorylase (PYGM) differs from other PG isoforms in expression …

Three-dimensional (3D) liver cell models-a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of …

MA Tutty, D Movia, A Prina-Mello - Drug Delivery and Translational …, 2022 - Springer
Despite the exciting properties and wide-reaching applications of nanobiomaterials (NBMs)
in human health and medicine, their translation from bench to bedside is slow, with a …

[PDF][PDF] Zebrafish as An Emerging Model: An Important Testing Platform for Biomedical Science

A Dubey - Journal of Pharmaceutical Negative Results, 2022 - pnrjournal.com
This is a good thing because animals show other organisms how to stay healthy in their
environment. Biologists can learn more about a lot ofdifferent biological processes by …

Pre-clinical models of metastasis in pancreatic cancer

M Miquel, S Zhang, C Pilarsky - Frontiers in cell and developmental …, 2021 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) is a hostile solid malignancy coupled with an
extremely high mortality rate. Metastatic disease is already found in most patients at the time …

CD24+ CD44+ CD54+ EpCAM+ gastric cancer stem cells predict tumor progression and metastasis: clinical and experimental evidence

AA Gómez-Gallegos, L Ramírez-Vidal… - Stem Cell Research & …, 2023 - Springer
Background Gastric cancer (GC) is a leading cause of cancer-related deaths worldwide.
Specific and thorough identification of cancer cell subsets with higher tumorigenicity and …

Experimental models of hepatocellular carcinoma—a preclinical perspective

A Blidisel, I Marcovici, D Coricovac, F Hut… - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is characterized by a broad molecular
and genetic heterogeneity, which makes it a challenging subject in terms of the underlying …