Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
Innate immune evasion strategies of SARS-CoV-2
JM Minkoff, B tenOever - Nature Reviews Microbiology, 2023 - nature.com
Abstract SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been
associated with substantial global morbidity and mortality. Despite a tropism that is largely …
associated with substantial global morbidity and mortality. Despite a tropism that is largely …
Rapid assessment of SARS-CoV-2–evolved variants using virus-like particles
Efforts to determine why new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) variants demonstrate improved fitness have been limited to analyzing mutations in the …
2) variants demonstrate improved fitness have been limited to analyzing mutations in the …
Analysis of 6.4 million SARS-CoV-2 genomes identifies mutations associated with fitness
Repeated emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants with increased fitness underscores the value of rapid detection and characterization …
variants with increased fitness underscores the value of rapid detection and characterization …
Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions
Macromolecular phase separation is thought to be one of the processes that drives the
formation of membraneless biomolecular condensates in cells. The dynamics of phase …
formation of membraneless biomolecular condensates in cells. The dynamics of phase …
The SARS-CoV-2 nucleocapsid protein and its role in viral structure, biological functions, and a potential target for drug or vaccine mitigation
Z Bai, Y Cao, W Liu, J Li - Viruses, 2021 - mdpi.com
The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the world
is still expanding. Thus, there is an urgent need to better understand this novel virus and find …
is still expanding. Thus, there is an urgent need to better understand this novel virus and find …
A comprehensive review of COVID-19 virology, vaccines, variants, and therapeutics
L Forchette, W Sebastian, T Liu - Current medical science, 2021 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of
the coronavirus disease 2019 (COVID-19), has caused more than 179 million infections and …
the coronavirus disease 2019 (COVID-19), has caused more than 179 million infections and …
The SARS-CoV-2 nucleocapsid protein: its role in the viral life cycle, structure and functions, and use as a potential target in the development of vaccines and …
W Wu, Y Cheng, H Zhou, C Sun, S Zhang - Virology journal, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) continues to take a heavy toll on personal
health, healthcare systems, and economies around the globe. Scientists are expending …
health, healthcare systems, and economies around the globe. Scientists are expending …
Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity
Patients with Coronavirus disease 2019 exhibit low expression of interferon-stimulated
genes, contributing to a limited antiviral response. Uncovering the underlying mechanism of …
genes, contributing to a limited antiviral response. Uncovering the underlying mechanism of …
The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein
The multifunctional nucleocapsid (N) protein in SARS-CoV-2 binds the~ 30 kb viral RNA
genome to aid its packaging into the 80–90 nm membrane-enveloped virion. The N protein …
genome to aid its packaging into the 80–90 nm membrane-enveloped virion. The N protein …