Stem cell homing: From physiology to therapeutics

JL Liesveld, N Sharma, OS Aljitawi - Stem Cells, 2020 - academic.oup.com
Stem cell homing is a multistep endogenous physiologic process that is also used by
exogenously administered hematopoietic stem and progenitor cells (HSPCs). This multistep …

Nanoparticles for immune cytokine TRAIL-based cancer therapy

PPG Guimarães, S Gaglione, T Sewastianik… - ACS …, 2018 - ACS Publications
The immune cytokine tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has
received significant attention as a cancer therapeutic due to its ability to selectively trigger …

Advances of blood cell-based drug delivery systems

Y Sun, J Su, G Liu, J Chen, X Zhang, R Zhang… - European journal of …, 2017 - Elsevier
Blood cells, including erythrocytes, leukocytes and platelets are used as drug carriers in a
wide range of applications. They have many unique advantages such as long life-span in …

Lamin A/C deficiency reduces circulating tumor cell resistance to fluid shear stress

MJ Mitchell, C Denais, MF Chan… - … of Physiology-Cell …, 2015 - journals.physiology.org
Metastasis contributes to over 90% of cancer-related deaths and is initiated when cancer
cells detach from the primary tumor, invade the basement membrane, and enter the …

Physical biology in cancer. 3. The role of cell glycocalyx in vascular transport of circulating tumor cells

MJ Mitchell, MR King - American Journal of Physiology-Cell …, 2014 - journals.physiology.org
Circulating tumor cells (CTCs) in blood are known to adhere to the luminal surface of the
microvasculature via receptor-mediated adhesion, which contributes to the spread of cancer …

Leukocytes as carriers for targeted cancer drug delivery

MJ Mitchell, MR King - Expert opinion on drug delivery, 2015 - Taylor & Francis
Introduction: Metastasis contributes to over 90% of cancer-related deaths. Numerous
nanoparticle platforms have been developed to target and treat cancer, yet efficient delivery …

[HTML][HTML] Fluid shear stress increases neutrophil activation via platelet-activating factor

MJ Mitchell, KS Lin, MR King - Biophysical journal, 2014 - cell.com
Leukocyte exposure to hemodynamic shear forces is critical for physiological functions
including initial adhesion to the endothelium, the formation of pseudopods, and migration …

Surfactant functionalization induces robust, differential adhesion of tumor cells and blood cells to charged nanotube-coated biomaterials under flow

MJ Mitchell, CA Castellanos, MR King - Biomaterials, 2015 - Elsevier
The metastatic spread of cancer cells from the primary tumor to distant sites leads to a poor
prognosis in cancers originating from multiple organs. Increasing evidence has linked …

Label-free microfluidic stem cell isolation technologies

A Menachery, N Kumawat, M Qasaimeh - TrAC Trends in Analytical …, 2017 - Elsevier
Stem cell research has great potential in clinical applications and regenerative medicine,
which highlight the need for efficient stem cell isolation technologies. Enrichment of stem …

Immobilized surfactant‐nanotube complexes support selectin‐mediated capture of viable circulating tumor cells in the absence of capture antibodies

MJ Mitchell, CA Castellanos… - Journal of Biomedical …, 2015 - Wiley Online Library
The metastatic spread of tumor cells from the primary site to anatomically distant organs
leads to a poor patient prognosis. Increasing evidence has linked adhesive interactions …