Glomerular hyperfiltration in diabetes: mechanisms, clinical significance, and treatment

L Tonneijck, MHA Muskiet, MM Smits… - Journal of the …, 2017 - journals.lww.com
An absolute, supraphysiologic elevation in GFR is observed early in the natural history in
10%–67% and 6%–73% of patients with type 1 and type 2 diabetes, respectively. Moreover …

[HTML][HTML] Evaluation and management of youth-onset type 2 diabetes: a position statement by the American Diabetes Association

S Arslanian, F Bacha, M Grey, MD Marcus… - Diabetes …, 2018 - ncbi.nlm.nih.gov
Although all types of diabetes result in hyperglycemia, the pathophysiology of each type of
diabetes is different. These guidelines summarize available data specific to the …

Dapagliflozin in focal segmental glomerulosclerosis: a combined human-rodent pilot study

H Rajasekeran, HN Reich… - American Journal …, 2018 - journals.physiology.org
Focal segmental glomerulosclerosis (FSGS) is an important cause of nondiabetic chronic
kidney disease (CKD). Sodium-glucose cotransporter 2 inhibition (SGLT2i) therapy …

Dipeptidyl Peptidase 4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1α1-67 in Patients With Type 2 Diabetes

JA Lovshin, H Rajasekeran, Y Lytvyn… - Diabetes …, 2017 - Am Diabetes Assoc
OBJECTIVE Antihyperglycemic agents, such as empagliflozin, stimulate proximal tubular
natriuresis and improve cardiovascular and renal outcomes in patients with type 2 diabetes …

[HTML][HTML] Eucommia ulmoides (Tochu) and its extract geniposidic acid reduced blood pressure and improved renal hemodynamics

A Ishimitsu, A Tojo, H Satonaka, T Ishimitsu - Biomedicine & …, 2021 - Elsevier
Introduction Eucommia ulmoides leaves are used as Tochu tea, which has a blood pressure
lowering effect of unknown mechanism. Purpose and Methods The effects of Tochu tea and …

Renal hemodynamic effects differ between antidiabetic combination strategies: randomized controlled clinical trial comparing empagliflozin/linagliptin with metformin …

C Ott, S Jung, M Korn, D Kannenkeril, A Bosch… - Cardiovascular …, 2021 - Springer
Background Type 2 diabetes causes cardio-renal complications and is treated with different
combination therapies. The renal hemodynamics profile of such combination therapies has …

Minireview: Understanding and targeting inflammatory, hemodynamic and injury markers for cardiorenal protection in type 1 diabetes

L Kugathasan, VS Sridhar, KL Tommerdahl, C Xu… - Metabolism, 2024 - Elsevier
The coexistence of cardiovascular disease (CVD) and diabetic kidney disease (DKD) is
common in people with type 1 diabetes (T1D) and is strongly associated with an increased …

Pima Indian contributions to our understanding of diabetic kidney disease

RG Nelson, WC Knowler, M Kretzler, KV Lemley… - Diabetes, 2021 - Am Diabetes Assoc
Prospective studies in informative populations are crucial to increasing our knowledge of
disease. In this perspective, we describe a half century of studies in an American Indian …

Perspectives on the role of magnetic resonance imaging (MRI) for noninvasive evaluation of diabetic kidney disease

JM Mora-Gutiérrez, MA Fernández-Seara… - Journal of Clinical …, 2021 - mdpi.com
Renal magnetic resonance imaging (MRI) techniques are currently in vogue, as they provide
in vivo information on renal volume, function, metabolism, perfusion, oxygenation, and …

Renal hyperfiltration in adolescents with type 2 diabetes: physiology, sex differences, and implications for diabetic kidney disease

P Bjornstad, DZ Cherney - Current diabetes reports, 2018 - Springer
Abstract Purpose of Review Compared to adult-onset type 2 diabetes (T2D), youth with T2D
have a more aggressive phenotype with greater insulin resistance (IR), more rapid β cell …